PMID- 23116264
OWN - NLM
STAT- MEDLINE
DCOM- 20140224
LR  - 20190923
IS  - 1875-5666 (Electronic)
IS  - 1566-5240 (Linking)
VI  - 13
IP  - 7
DP  - 2013 Aug
TI  - Nuclear hormone receptors and female reproduction.
PG  - 1066-78
AB  - BACKGROUND: Nuclear Hormone Receptors (NHR) are, as the name implies, receptors 
      located in the cell nucleus that have transcription modulating characteristics. 
      Activated non-steroidal lipophilic ligands bind these receptors resulting in 
      dimerisation of the ligands, DNA-binding and transcriptional regulation of target 
      proteins that influence especially cell differentiation, metabolic homeostasis 
      and embryogenesis. METHODS: This review is based on publications derived from 
      PubMed based pursuit of scientific literature in conjunction with the authors' 
      experience. RESULTS: Here, a summary of NHR family members (RXR, PPAR, VDR, TR) 
      first in respect to known general aspects such as ligands, binding domains, 
      signalling mechanism and second focussing especially their influence on female 
      reproduction is offered. Furthermore, crosstalk with other prominent signalling 
      proteins important to trophoblast function [signal transducer and activator of 
      transcription (STAT), mitogen-activated protein kinase (MAPK), nuclear factor 
      'kappa-light-chain-enhancer' of activated B-cells (NFkappaB), Akt/ 
      phosphaidyl-3-kinase (PI3K), and Wnt, are described. CONCLUSION: Considering 
      their attributes, it is not surprising that NHR family members play a central 
      role in female reproduction by targeting cell differentiation, metabolic 
      homeostasis and embryogenesis. However, it seems that crosstalk depends on stage 
      of trophoblast differentiation.
FAU - Pestka, A
AU  - Pestka A
AD  - Ludwig Maximilians University of Munich, Department of Gynaecology and 
      Obstetrics, Maistrasse 11, D-80337 Munich, Germany.
FAU - Fitzgerald, J S
AU  - Fitzgerald JS
FAU - Toth, B
AU  - Toth B
FAU - Markert, U R
AU  - Markert UR
FAU - Jeschke, U
AU  - Jeschke U
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - Netherlands
TA  - Curr Mol Med
JT  - Current molecular medicine
JID - 101093076
RN  - 0 (Ligands)
RN  - 0 (Receptors, Cytoplasmic and Nuclear)
SB  - IM
MH  - Cell Differentiation/*genetics
MH  - Embryonic Development/genetics
MH  - Female
MH  - Gene Expression Regulation
MH  - Humans
MH  - Ligands
MH  - Receptors, Cytoplasmic and Nuclear/*genetics
MH  - Reproduction/*genetics/physiology
MH  - Signal Transduction
MH  - Trophoblasts/cytology/*metabolism
EDAT- 2012/11/03 06:00
MHDA- 2014/02/25 06:00
CRDT- 2012/11/03 06:00
PHST- 2012/03/15 00:00 [received]
PHST- 2012/10/21 00:00 [revised]
PHST- 2012/10/26 00:00 [accepted]
PHST- 2012/11/03 06:00 [entrez]
PHST- 2012/11/03 06:00 [pubmed]
PHST- 2014/02/25 06:00 [medline]
AID - CMM-EPUB-20121031-2 [pii]
AID - 10.2174/1566524011313070002 [doi]
PST - ppublish
SO  - Curr Mol Med. 2013 Aug;13(7):1066-78. doi: 10.2174/1566524011313070002.