PMID- 23117450
OWN - NLM
STAT- MEDLINE
DCOM- 20150708
LR  - 20181202
IS  - 1672-7347 (Print)
IS  - 1672-7347 (Linking)
VI  - 37
IP  - 10
DP  - 2012 Oct
TI  - [Detection of chromosomal aberrations in multiple myeloma with fluorescence in 
      situ hybridization].
PG  - 983-9
LID - 10.3969/j.issn.1672-7347.2012.10.003 [doi]
AB  - OBJECTIVE: To detect of chromosomal abnormalities in multiple myeloma (MM) 
      patients with fluorescence in situ hybridization (FISH). METHODS: FISH was 
      performed in 20 MM patients using 5 specific DNA probes. The difference in 
      chromosomal abnormalities was compared by FISH and other routine cytogenetic 
      tests. RESULTS: Eighteen of the 20 patients showed chromosomal abnormalities 
      (90%). The positive rates of t(14q32), del(13q14), dup(1q21), and p53 gene were 
      65% (13 in 20), 55% (11 in 20), 25% (5 in 20), and 15%(3 in 20), respectively. 
      The abnormal rate of the conventional chromosome examination was 15% only. 
      CONCLUSION: FISH is more sensitive than traditional chromosomal tests and can be 
      used as an index in prognostic evaluation for MM. Del(13q14) and t(14q32) are the 
      most common chromosomal abnormalities in MM patients.
FAU - Cao, Pengfei
AU  - Cao P
AD  - Department of Hematology, Xiangya Hospital, Changsha, China.
FAU - Chen, Fangping
AU  - Chen F
FAU - Cheng, Ye
AU  - Cheng Y
LA  - chi
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Zhong Nan Da Xue Xue Bao Yi Xue Ban
JT  - Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. 
      Medical sciences
JID - 101230586
SB  - IM
MH  - *Chromosome Aberrations
MH  - Chromosomes, Human, Pair 1
MH  - Chromosomes, Human, Pair 13
MH  - Chromosomes, Human, Pair 14
MH  - Humans
MH  - *In Situ Hybridization, Fluorescence
MH  - Multiple Myeloma/*genetics
MH  - Prognosis
EDAT- 2012/11/03 06:00
MHDA- 2015/07/15 06:00
CRDT- 2012/11/03 06:00
PHST- 2012/11/03 06:00 [entrez]
PHST- 2012/11/03 06:00 [pubmed]
PHST- 2015/07/15 06:00 [medline]
AID - 10.3969/j.issn.1672-7347.2012.10.003 [doi]
PST - ppublish
SO  - Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2012 Oct;37(10):983-9. doi: 
      10.3969/j.issn.1672-7347.2012.10.003.