PMID- 23117801
OWN - NLM
STAT- MEDLINE
DCOM- 20130329
LR  - 20191210
IS  - 1560-2281 (Electronic)
IS  - 1083-3668 (Linking)
VI  - 17
IP  - 11
DP  - 2012 Nov
TI  - Assessment of the effects of ultrasound-mediated glucose on permeability of 
      normal, benign, and cancerous human lung tissues with the Fourier-domain optical 
      coherence tomography.
PG  - 116006
LID - 10.1117/1.JBO.17.11.116006 [doi]
AB  - The objective of this study was to evaluate the effects of ultrasound-mediated 
      analyte diffusion on permeability of normal, benign, and cancerous human lung 
      tissue in vitro and to find more effective sonophoretic (SP) delivery in 
      combination with the optical clearing agents (OCAs) method to distinguish normal 
      and diseased lung tissues. The permeability coefficients of SP in combination 
      with OCAs diffusion in lung tissue were measured with Fourier-domain optical 
      coherence tomography (FD-OCT). 30% glucose and SP with a frequency of 1 MHz and 
      an intensity of 0.80  W/cm2 over a 3 cm probe was simultaneously applied for 15 
      min. Experimental results show that the mean permeability coefficients of 30% 
      glucose/SP were found to be (2.01+/-0.21)x10(-5)  cm/s from normal lung (NL) 
      tissue, (2.75+/-0.28)x10(-5)  cm/s from lung benign granulomatosis (LBG) tissue, 
      (4.53+/-0.49)x10(-5)  cm/s from lung adenocarcinoma tumor (LAT) tissue, and 
      (5.81+/-0.62)x10(-5)  cm/s from lung squamous cell carcinoma (LSCC) tissue, 
      respectively. The permeability coefficients of 30% glucose/SP increase 
      approximately 36.8%, 125.4%, and 189.1% for the LBG, LAT, and LSCC tissue 
      compared with that for the NL tissue, respectively. There were statistically 
      significant differences in permeability coefficients of 30% glucose/SP between 
      LBG and NL tissue (p<0.05), between LAT and NL tissue (p<0.05), and between LSCC 
      and NL tissue (p<0.05). The results suggest that the OCT functional imaging 
      technique to combine an ultrasound-OCAs combination method could become a 
      powerful tool in early diagnosis and monitoring of changed microstructure of 
      pathologic human lung tissue.
FAU - Wei, Huajiang
AU  - Wei H
AD  - South China Normal University, College of Biophotonics, MOE Key Laboratory of 
      Laser Life Science & Institute of Laser Life Science, Guangzhou 510631, Guangdong 
      Province, China. weihj@scnu.edu.cn
FAU - Wu, Guoyong
AU  - Wu G
FAU - Guo, Zhouyi
AU  - Guo Z
FAU - Yang, Hongqin
AU  - Yang H
FAU - He, Yonghong
AU  - He Y
FAU - Xie, Shusen
AU  - Xie S
FAU - Guo, Xiao
AU  - Guo X
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Biomed Opt
JT  - Journal of biomedical optics
JID - 9605853
RN  - IY9XDZ35W2 (Glucose)
SB  - IM
MH  - Adenocarcinoma/metabolism
MH  - Carcinoma, Squamous Cell/metabolism
MH  - Fourier Analysis
MH  - Glucose/administration & dosage/*pharmacokinetics
MH  - Granuloma, Respiratory Tract/metabolism
MH  - Humans
MH  - Lung/*metabolism
MH  - Lung Diseases/diagnosis/*metabolism
MH  - Lung Neoplasms/diagnosis/*metabolism
MH  - Optical Phenomena
MH  - Permeability
MH  - Tomography, Optical Coherence/*methods/statistics & numerical data
MH  - Ultrasonics
EDAT- 2012/11/03 06:00
MHDA- 2013/03/30 06:00
CRDT- 2012/11/03 06:00
PHST- 2012/11/03 06:00 [entrez]
PHST- 2012/11/03 06:00 [pubmed]
PHST- 2013/03/30 06:00 [medline]
AID - 1388597 [pii]
AID - 10.1117/1.JBO.17.11.116006 [doi]
PST - ppublish
SO  - J Biomed Opt. 2012 Nov;17(11):116006. doi: 10.1117/1.JBO.17.11.116006.