PMID- 23118644
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121105
LR  - 20220410
IS  - 1551-6776 (Print)
IS  - 1551-6776 (Linking)
VI  - 11
IP  - 1
DP  - 2006 Jan
TI  - Propofol-related infusion syndrome in critically ill pediatric patients: 
      coincidence, association, or causation?
PG  - 17-42
LID - 10.5863/1551-6776-11.1.17 [doi]
AB  - Over the past two decades numerous reports have described the development of a 
      propofol-related infusion syndrome (PRIS) in critically ill adult and pediatric 
      patients who received continuous infusion propofol for anesthesia or sedation. 
      The syndrome is generally characterized by progressive metabolic acidosis, 
      hemodynamic instability and bradyarrhythmias that are refractory to aggressive 
      pharmacological treatments. PRIS may occur with or without the presence of 
      hepatomegaly, rhabdomyolysis or lipemia. To date, the medical literature contains 
      accounts of 20 deaths in critically ill pediatric patients who developed features 
      consistent with PRIS. These reports have generated considerable discussion and 
      debate regarding the relationship, if any, between propofol and a constellation 
      of clinical symptoms and features that have been attributed to its use in 
      critically ill pediatric patients. This paper reviews the literature concerning 
      PRIS, its clinical presentation, proposed mechanisms for the syndrome, and 
      potential management should the syndrome occur.
FAU - Timpe, Erin M
AU  - Timpe EM
AD  - Department of Pharmacy Practice, Southern Illinois University Edwardsville, 
      Edwardsville, Illinois.
FAU - Eichner, Samantha F
AU  - Eichner SF
FAU - Phelps, Stephanie J
AU  - Phelps SJ
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Pediatr Pharmacol Ther
JT  - The journal of pediatric pharmacology and therapeutics : JPPT : the official 
      journal of PPAG
JID - 101089851
PMC - PMC3468086
OTO - NOTNLM
OT  - adverse effect
OT  - lipemia
OT  - metabolic acidosis
OT  - pediatric intensive care
OT  - propofol infusion syndrome
OT  - sedation
EDAT- 2006/01/01 00:00
MHDA- 2006/01/01 00:01
PMCR- 2006/01/01
CRDT- 2012/11/03 06:00
PHST- 2012/11/03 06:00 [entrez]
PHST- 2006/01/01 00:00 [pubmed]
PHST- 2006/01/01 00:01 [medline]
PHST- 2006/01/01 00:00 [pmc-release]
AID - 10.5863/1551-6776-11.1.17 [doi]
PST - ppublish
SO  - J Pediatr Pharmacol Ther. 2006 Jan;11(1):17-42. doi: 10.5863/1551-6776-11.1.17.