PMID- 23118687
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121105
LR  - 20211021
IS  - 1551-6776 (Print)
IS  - 1551-6776 (Linking)
VI  - 9
IP  - 1
DP  - 2004 Jan
TI  - Type 2 diabetes mellitus in children and adolescents: the new challenge.
PG  - 15-26
LID - 10.5863/1551-6776-9.1.15 [doi]
AB  - The epidemic increase in the incidence of type 2 diabetes mellitus (T2DM) in 
      children and adolescents is presenting enormous challenges to the medical 
      profession. The combination of factors such as obesity, ethnicity, puberty, and 
      genetic predisposition has contributed to the development of T2DM in younger 
      ages. These factors affect the regulatory mechanism of insulin secretion, insulin 
      action, and hepatic gluconeogenesis. In contrast to adults, children appear to 
      have a shorter latency to disease, a more rapid development of symptoms, and an 
      increased ketoacidosis. There are limited therapeutic options to prevent or 
      manage T2DM in children. Although the role of diet and exercise (lifestyle 
      intervention) has not been adequately evaluated in children, they will remain 
      important adjuncts in the prevention and treatment of T2DM. Insulin and metformin 
      are currently the only approved medications for the treatment of T2DM in 
      children. Clinical trials involving other oral agents used in adults are 
      currently being conducted to evaluate their safety and efficacy in children.
FAU - Christensen, Michael L
AU  - Christensen ML
AD  - Department of Pharmacy, Pediatric Pharmacology Research Unit, Center for 
      Pediatric Pharmacokinetics and Therapeutic, Memphis, Tennessee ; Department of 
      Pediatrics, Memphis, Tennessee ; Children's Foundation Research Center, LeBonheur 
      Children's Medical Center, Memphis, Tennessee.
FAU - Rashed, Sahar M
AU  - Rashed SM
FAU - Sinclair, Julie
AU  - Sinclair J
FAU - Cowan, Patricia A
AU  - Cowan PA
FAU - Velasquez-Mieyer, Pedro
AU  - Velasquez-Mieyer P
FAU - Burghen, George A
AU  - Burghen GA
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Pediatr Pharmacol Ther
JT  - The journal of pediatric pharmacology and therapeutics : JPPT : the official 
      journal of PPAG
JID - 101089851
PMC - PMC3469145
OTO - NOTNLM
OT  - drug therapy
OT  - obesity
OT  - pediatrics
OT  - type 2 diabetes mellitus
EDAT- 2004/01/01 00:00
MHDA- 2004/01/01 00:01
PMCR- 2004/01/01
CRDT- 2012/11/03 06:00
PHST- 2012/11/03 06:00 [entrez]
PHST- 2004/01/01 00:00 [pubmed]
PHST- 2004/01/01 00:01 [medline]
PHST- 2004/01/01 00:00 [pmc-release]
AID - 10.5863/1551-6776-9.1.15 [doi]
PST - ppublish
SO  - J Pediatr Pharmacol Ther. 2004 Jan;9(1):15-26. doi: 10.5863/1551-6776-9.1.15.