PMID- 23121123
OWN - NLM
STAT- MEDLINE
DCOM- 20130809
LR  - 20220310
IS  - 1365-2265 (Electronic)
IS  - 0300-0664 (Linking)
VI  - 78
IP  - 3
DP  - 2013 Mar
TI  - The role of obesity and type 2 diabetes mellitus in the development of male 
      obesity-associated secondary hypogonadism.
PG  - 330-7
LID - 10.1111/cen.12092 [doi]
AB  - Obesity, secondary (hypogonadotrophic) hypogonadism (SH), sleep disorders [such 
      as obstructive sleep apnoea (OSA)] and type 2 diabetes mellitus (T2DM) in men 
      have complex interlinks both with respect to mutual aetiopathogenesis as well as 
      therapeutics. Correction of the attendant hypogonadism in obese men may serve to 
      break this link and have beneficial effects beyond restoration of normal sexual 
      function. Male obesity-associated secondary hypogonadism (MOSH) should be 
      regarded as a distinct clinical entity and subtype of SH. A high index of 
      suspicion for the presence of MOSH must be maintained by clinicians when 
      assessing obese men. The pathogenesis of MOSH remains incompletely understood. 
      Furthermore, the optimal management of MOSH and its associated sequelae will 
      require long-term prospective studies that in turn will inform the development of 
      future clinical guidelines for this important and prevalent condition.
CI  - (c) 2012 Blackwell Publishing Ltd.
FAU - Saboor Aftab, S A
AU  - Saboor Aftab SA
AD  - Clinical Sciences Research Laboratories, Division of Metabolic and Vascular 
      Health, Warwick Medical School, The University of Warwick, University Hospitals 
      Coventry and Warwickshire, Coventry, UK.
FAU - Kumar, S
AU  - Kumar S
FAU - Barber, T M
AU  - Barber TM
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Clin Endocrinol (Oxf)
JT  - Clinical endocrinology
JID - 0346653
SB  - IM
CIN - Clin Endocrinol (Oxf). 2014 Mar;80(3):464. PMID: 23647503
MH  - Diabetes Mellitus, Type 2/epidemiology/metabolism/*pathology
MH  - Humans
MH  - Hypogonadism/epidemiology/metabolism/*pathology
MH  - Male
MH  - Obesity/epidemiology/metabolism/*pathology
MH  - Sleep Apnea, Obstructive/epidemiology/metabolism/pathology
EDAT- 2012/11/06 06:00
MHDA- 2013/08/10 06:00
CRDT- 2012/11/06 06:00
PHST- 2012/05/31 00:00 [received]
PHST- 2012/07/02 00:00 [revised]
PHST- 2012/09/25 00:00 [revised]
PHST- 2012/10/30 00:00 [accepted]
PHST- 2012/11/06 06:00 [entrez]
PHST- 2012/11/06 06:00 [pubmed]
PHST- 2013/08/10 06:00 [medline]
AID - 10.1111/cen.12092 [doi]
PST - ppublish
SO  - Clin Endocrinol (Oxf). 2013 Mar;78(3):330-7. doi: 10.1111/cen.12092.