PMID- 23121543
OWN - NLM
STAT- MEDLINE
DCOM- 20140710
LR  - 20220318
IS  - 1465-3656 (Electronic)
IS  - 1355-4794 (Print)
IS  - 1355-4794 (Linking)
VI  - 20
IP  - 1
DP  - 2014
TI  - Agraphia in patients with frontotemporal dementia and parkinsonism linked to 
      chromosome 17 with P301L MAPT mutation: dysexecutive, aphasic, apraxic or spatial 
      phenomenon?
PG  - 69-86
LID - 10.1080/13554794.2012.732087 [doi]
AB  - OBJECTIVES: Patients with frontotemporal dementia and parkinsonism linked to 
      chromosome 17 (FTDP-17) may be agraphic. The study aimed at characterizing 
      agraphia in individuals with a P301L MAPT mutation. METHODS: Two pairs of 
      siblings with FTDP-17 were longitudinally examined for agraphia in relation to 
      language and cognitive deficits. RESULTS: All patients presented with 
      dysexecutive agraphia. In addition, in the first pair of siblings one sibling 
      demonstrated spatial agraphia with less pronounced allographic agraphia and the 
      other sibling had aphasic agraphia. Aphasic agraphia was also present in one 
      sibling from the second pair. CONCLUSION: Agraphia associated with FTDP-17 is 
      very heterogeneous.
FAU - Sitek, Emilia J
AU  - Sitek EJ
AD  - a Department of Neurology , St. Adalbert Hospital , Gdansk , Poland.
FAU - Narozanska, Ewa
AU  - Narozanska E
FAU - Barczak, Anna
AU  - Barczak A
FAU - Jasinska-Myga, Barbara
AU  - Jasinska-Myga B
FAU - Harciarek, Michal
AU  - Harciarek M
FAU - Chodakowska-Zebrowska, Malgorzata
AU  - Chodakowska-Zebrowska M
FAU - Kubiak, Malgorzata
AU  - Kubiak M
FAU - Wieczorek, Dariusz
AU  - Wieczorek D
FAU - Konieczna, Seweryna
AU  - Konieczna S
FAU - Rademakers, Rosa
AU  - Rademakers R
FAU - Baker, Matt
AU  - Baker M
FAU - Berdynski, Mariusz
AU  - Berdynski M
FAU - Brockhuis, Bogna
AU  - Brockhuis B
FAU - Barcikowska, Maria
AU  - Barcikowska M
FAU - Zekanowski, Cezary
AU  - Zekanowski C
FAU - Heilman, Kenneth M
AU  - Heilman KM
FAU - Wszolek, Zbigniew K
AU  - Wszolek ZK
FAU - Slawek, Jaroslaw
AU  - Slawek J
LA  - eng
GR  - NS057567/NS/NINDS NIH HHS/United States
GR  - P50NS072187/NS/NINDS NIH HHS/United States
GR  - P50 NS072187/NS/NINDS NIH HHS/United States
GR  - R01 NS065782/NS/NINDS NIH HHS/United States
GR  - 1RC2NS070276/NS/NINDS NIH HHS/United States
GR  - R01 NS057567/NS/NINDS NIH HHS/United States
GR  - NS65782/NS/NINDS NIH HHS/United States
GR  - RC2 NS070276/NS/NINDS NIH HHS/United States
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20121105
PL  - England
TA  - Neurocase
JT  - Neurocase
JID - 9511374
RN  - 0 (MAPT protein, human)
RN  - 0 (tau Proteins)
SB  - IM
MH  - Agraphia/*diagnosis/*genetics
MH  - Brain/pathology
MH  - *Chromosomes, Human, Pair 17
MH  - Disease Progression
MH  - Female
MH  - Frontotemporal Dementia/*genetics/pathology/psychology
MH  - Humans
MH  - Longitudinal Studies
MH  - Male
MH  - Middle Aged
MH  - Mutation
MH  - Parkinsonian Disorders/*genetics/pathology/psychology
MH  - tau Proteins/*genetics
PMC - PMC3710298
MID - NIHMS453554
EDAT- 2012/11/06 06:00
MHDA- 2014/07/11 06:00
PMCR- 2014/02/01
CRDT- 2012/11/06 06:00
PHST- 2012/11/06 06:00 [entrez]
PHST- 2012/11/06 06:00 [pubmed]
PHST- 2014/07/11 06:00 [medline]
PHST- 2014/02/01 00:00 [pmc-release]
AID - 10.1080/13554794.2012.732087 [doi]
PST - ppublish
SO  - Neurocase. 2014;20(1):69-86. doi: 10.1080/13554794.2012.732087. Epub 2012 Nov 5.