PMID- 23122676
OWN - NLM
STAT- MEDLINE
DCOM- 20130530
LR  - 20121130
IS  - 1878-5905 (Electronic)
IS  - 0142-9612 (Linking)
VI  - 34
IP  - 4
DP  - 2013 Jan
TI  - Induction of rat facial nerve regeneration by functional collagen scaffolds.
PG  - 1302-10
LID - S0142-9612(12)01152-0 [pii]
LID - 10.1016/j.biomaterials.2012.10.031 [doi]
AB  - Nerve conduit provides a promising strategy for nerve regeneration, and the 
      proper microenvironment in the lumen could improve the regeneration. Our previous 
      work had demonstrated that linear ordered collagen scaffold (LOCS) could 
      effectively guide the oriented growth of axons. Laminin is known as an important 
      nerve growth promoting factor and can facilitate the growth cone formation. In 
      addition, ciliary neurotrophic factor (CNTF) and brain-derived neurotrophic 
      factor (BDNF) can effectively improve the nerve regeneration after nerve 
      injuries. However, in practice, diffusion caused by the body fluids is the major 
      obstacle in their applications. To retain CNTF or BDNF on the scaffolds, we 
      produced collagen binding CNTF (CBD-CNTF), collagen binding BDNF (CBD-BDNF) and 
      laminin binding CNTF (LBD-CNTF), laminin binding BDNF (LBD-BDNF) respectively. In 
      this work, we developed laminin modified LOCS fibers (L x LOCS) by chemical 
      cross-linking LOCS fibers with laminin. Collagen binding or laminin binding 
      neurotrophic factors were combined with LOCS or L x LOCS, and then filled them 
      into the collagen nerve conduit. They were found to guide the ordered growth of 
      axons, and improve the nerve functional recovery in the rat facial nerve 
      transection model. The combination of CNTF and BDNF greatly enhanced the facial 
      nerve regeneration and functional recovery.
CI  - Copyright (c) 2012 Elsevier Ltd. All rights reserved.
FAU - Cao, Jiani
AU  - Cao J
AD  - State Key Laboratory of Molecular Developmental Biology, Institute of Genetics 
      and Developmental Biology, Chinese Academy of Sciences, 3 Nanyitiao, 
      Zhongguancun, Beijing 100190, China.
FAU - Xiao, Zhifeng
AU  - Xiao Z
FAU - Jin, Wei
AU  - Jin W
FAU - Chen, Bing
AU  - Chen B
FAU - Meng, Danqing
AU  - Meng D
FAU - Ding, Wenyong
AU  - Ding W
FAU - Han, Sufang
AU  - Han S
FAU - Hou, Xiaoshan
AU  - Hou X
FAU - Zhu, Tiansheng
AU  - Zhu T
FAU - Yuan, Baoyu
AU  - Yuan B
FAU - Wang, Jing
AU  - Wang J
FAU - Liang, Weibang
AU  - Liang W
FAU - Dai, Jianwu
AU  - Dai J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121031
PL  - Netherlands
TA  - Biomaterials
JT  - Biomaterials
JID - 8100316
RN  - 0 (Nanocapsules)
RN  - 0 (Nerve Growth Factors)
RN  - 9007-34-5 (Collagen)
SB  - IM
MH  - Animals
MH  - Collagen/*chemistry
MH  - Equipment Design
MH  - Equipment Failure Analysis
MH  - Facial Nerve Injuries/pathology/*physiopathology/*therapy
MH  - Female
MH  - Guided Tissue Regeneration/instrumentation
MH  - Nanocapsules/*administration & dosage
MH  - Nerve Growth Factors/*administration & dosage
MH  - Nerve Regeneration/*physiology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - *Tissue Scaffolds
MH  - Treatment Outcome
EDAT- 2012/11/06 06:00
MHDA- 2013/06/01 06:00
CRDT- 2012/11/06 06:00
PHST- 2012/09/17 00:00 [received]
PHST- 2012/10/10 00:00 [accepted]
PHST- 2012/11/06 06:00 [entrez]
PHST- 2012/11/06 06:00 [pubmed]
PHST- 2013/06/01 06:00 [medline]
AID - S0142-9612(12)01152-0 [pii]
AID - 10.1016/j.biomaterials.2012.10.031 [doi]
PST - ppublish
SO  - Biomaterials. 2013 Jan;34(4):1302-10. doi: 10.1016/j.biomaterials.2012.10.031. 
      Epub 2012 Oct 31.