PMID- 23123199
OWN - NLM
STAT- MEDLINE
DCOM- 20130628
LR  - 20240213
IS  - 1090-2139 (Electronic)
IS  - 0889-1591 (Print)
IS  - 0889-1591 (Linking)
VI  - 28
DP  - 2013 Feb
TI  - Neurobiological markers of exercise-related brain plasticity in older adults.
PG  - 90-9
LID - S0889-1591(12)00483-7 [pii]
LID - 10.1016/j.bbi.2012.10.021 [doi]
AB  - The current study examined how a randomized one-year aerobic exercise program for 
      healthy older adults would affect serum levels of brain-derived neurotrophic 
      factor (BDNF), insulin-like growth factor type 1 (IGF-1), and vascular 
      endothelial growth factor (VEGF) - putative markers of exercise-induced benefits 
      on brain function. The study also examined whether (a) change in the 
      concentration of these growth factors was associated with alterations in 
      functional connectivity following exercise, and (b) the extent to which 
      pre-intervention growth factor levels were associated with training-related 
      changes in functional connectivity. In 65 participants (mean age=66.4), we found 
      that although there were no group-level changes in growth factors as a function 
      of the intervention, increased temporal lobe connectivity between the bilateral 
      parahippocampus and the bilateral middle temporal gyrus was associated with 
      increased BDNF, IGF-1, and VEGF for an aerobic walking group but not for a 
      non-aerobic control group, and greater pre-intervention VEGF was associated with 
      greater training-related increases in this functional connection. Results are 
      consistent with animal models of exercise and the brain, but are the first to 
      show in humans that exercise-induced increases in temporal lobe functional 
      connectivity are associated with changes in growth factors and may be augmented 
      by greater baseline VEGF.
CI  - Copyright (c) 2012 Elsevier Inc. All rights reserved.
FAU - Voss, Michelle W
AU  - Voss MW
AD  - The University of Iowa, Department of Psychology, IA 52242, United States. 
      michelle-voss@uiowa.edu
FAU - Erickson, Kirk I
AU  - Erickson KI
FAU - Prakash, Ruchika Shaurya
AU  - Prakash RS
FAU - Chaddock, Laura
AU  - Chaddock L
FAU - Kim, Jennifer S
AU  - Kim JS
FAU - Alves, Heloisa
AU  - Alves H
FAU - Szabo, Amanda
AU  - Szabo A
FAU - Phillips, Siobhan M
AU  - Phillips SM
FAU - Wojcicki, Thomas R
AU  - Wojcicki TR
FAU - Mailey, Emily L
AU  - Mailey EL
FAU - Olson, Erin A
AU  - Olson EA
FAU - Gothe, Neha
AU  - Gothe N
FAU - Vieira-Potter, Victoria J
AU  - Vieira-Potter VJ
FAU - Martin, Stephen A
AU  - Martin SA
FAU - Pence, Brandt D
AU  - Pence BD
FAU - Cook, Marc D
AU  - Cook MD
FAU - Woods, Jeffrey A
AU  - Woods JA
FAU - McAuley, Edward
AU  - McAuley E
FAU - Kramer, Arthur F
AU  - Kramer AF
LA  - eng
GR  - UL1 TR000005/TR/NCATS NIH HHS/United States
GR  - K25 AG033725/AG/NIA NIH HHS/United States
GR  - R37 AG025667/AG/NIA NIH HHS/United States
GR  - R37AG025667/AG/NIA NIH HHS/United States
GR  - R01 AG025032/AG/NIA NIH HHS/United States
GR  - R01 AG25032/AG/NIA NIH HHS/United States
GR  - R01 DK095172/DK/NIDDK NIH HHS/United States
GR  - R01 AG018008/AG/NIA NIH HHS/United States
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, N.I.H., Extramural
DEP - 20121102
PL  - Netherlands
TA  - Brain Behav Immun
JT  - Brain, behavior, and immunity
JID - 8800478
RN  - 0 (Biomarkers)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Vascular Endothelial Growth Factor A)
RN  - 67763-96-6 (Insulin-Like Growth Factor I)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Biomarkers/blood
MH  - Brain/physiology
MH  - Brain-Derived Neurotrophic Factor/*blood/physiology
MH  - Exercise/*physiology
MH  - Female
MH  - Functional Neuroimaging
MH  - Humans
MH  - Insulin-Like Growth Factor I/*analysis/physiology
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Neuronal Plasticity/*physiology
MH  - Neuropsychological Tests
MH  - Physical Fitness/physiology
MH  - Temporal Lobe/physiology
MH  - Vascular Endothelial Growth Factor A/analysis/*blood
PMC - PMC3544982
MID - NIHMS419388
EDAT- 2012/11/06 06:00
MHDA- 2013/07/03 06:00
PMCR- 2014/02/01
CRDT- 2012/11/06 06:00
PHST- 2012/06/20 00:00 [received]
PHST- 2012/10/24 00:00 [revised]
PHST- 2012/10/24 00:00 [accepted]
PHST- 2012/11/06 06:00 [entrez]
PHST- 2012/11/06 06:00 [pubmed]
PHST- 2013/07/03 06:00 [medline]
PHST- 2014/02/01 00:00 [pmc-release]
AID - S0889-1591(12)00483-7 [pii]
AID - 10.1016/j.bbi.2012.10.021 [doi]
PST - ppublish
SO  - Brain Behav Immun. 2013 Feb;28:90-9. doi: 10.1016/j.bbi.2012.10.021. Epub 2012 
      Nov 2.