PMID- 23123338
OWN - NLM
STAT- MEDLINE
DCOM- 20130530
LR  - 20161125
IS  - 1873-3344 (Electronic)
IS  - 0162-0134 (Linking)
VI  - 118
DP  - 2013 Jan
TI  - Synthesis, characterization, DNA binding properties and antioxidant activity of a 
      manganese(II) complex with NO6 chromophore.
PG  - 48-58
LID - S0162-0134(12)00301-7 [pii]
LID - 10.1016/j.jinorgbio.2012.09.015 [doi]
AB  - The mononuclear complex [Mn(thiophenyl-2-carboxylate)(2)(H(3)tea)] (1), where 
      H(3)tea=triethanolamine has been synthesized, characterized, while the DNA 
      binding properties and the antioxidant activity were studied. The crystal 
      structure of 1 is also reported. The interaction between 1 and calf thymus double 
      stranded (ds) DNA was electrochemically at a calf thymus DNA (CT-DNA) modified 
      carbon paste electrode (CPE) and spectrophotometrically investigated, 
      respectively. Adsorptive transfer stripping voltammetry showed that the 
      interaction mode between 1 and CT-DNA depends on manganese(II) complex 
      concentration. UV studies between 1 and CT-DNA revealed that 1 can bind to CT-DNA 
      by the intercalative binding mode and the binding constant has been calculated. A 
      competitive study with acridine orange (AO) showed that 1 exhibits the ability to 
      displace the DNA-bound AO, since 1 binds to the DNA in competition with AO. In 
      vitro antioxidant activity of free ligands and 1 was evaluated using five 
      different antioxidant assays: a) interaction with 1, 1-diphenyl-2-picryl-hydrazyl 
      (DPPH) stable free radical, b) the EtaOmicron mediated oxidation of DMSO, c) scavenging 
      of superoxide anion radicals, d) inhibition of lipid peroxidation and e) soybean 
      lipoxygenase (LOX) inhibition. The results revealed the selectivity of the 
      manganese complex to different free radicals as a consequence of its 
      physicochemical feature. In particular, 1 presents significant inhibitory 
      activity on LOX, with IC(50)=30 muM and selectivity to the inhibition of 
      superoxide anion radicals and thus a promising candidate as a superoxide 
      dismutase (SOD) biomimetic.
CI  - Copyright (c) 2012 Elsevier Inc. All rights reserved.
FAU - Karastogianni, Sophia
AU  - Karastogianni S
AD  - Department of Analytical Chemistry, Aristotle University of Thessaloniki, 
      Thessaloniki 54124, Greece.
FAU - Dendrinou-Samara, Catherine
AU  - Dendrinou-Samara C
FAU - Ioannou, Eleutheria
AU  - Ioannou E
FAU - Raptopoulou, Catherine P
AU  - Raptopoulou CP
FAU - Hadjipavlou-Litina, Demetra
AU  - Hadjipavlou-Litina D
FAU - Girousi, Stella
AU  - Girousi S
LA  - eng
PT  - Journal Article
DEP - 20120923
PL  - United States
TA  - J Inorg Biochem
JT  - Journal of inorganic biochemistry
JID - 7905788
RN  - 0 (Biphenyl Compounds)
RN  - 0 (Free Radical Scavengers)
RN  - 0 (Free Radicals)
RN  - 0 (Intercalating Agents)
RN  - 0 (Lipoxygenase Inhibitors)
RN  - 0 (Mn(thiophenyl-2-carboxylate)(2)(H(3)triethanolamine))
RN  - 0 (Organometallic Compounds)
RN  - 0 (Picrates)
RN  - 11062-77-4 (Superoxides)
RN  - 9007-49-2 (DNA)
RN  - 91080-16-9 (calf thymus DNA)
RN  - DFD3H4VGDH (1,1-diphenyl-2-picrylhydrazyl)
RN  - EC 1.13.11.- (lipoxygenase L-1)
RN  - EC 1.13.11.12 (Lipoxygenase)
RN  - F30N4O6XVV (Acridine Orange)
SB  - IM
MH  - Acridine Orange/chemistry
MH  - Adsorption
MH  - Binding, Competitive
MH  - Biphenyl Compounds/chemistry
MH  - Crystallography, X-Ray
MH  - DNA/*chemistry
MH  - Electrochemistry
MH  - Free Radical Scavengers/*chemical synthesis/chemistry
MH  - Free Radicals/chemistry
MH  - Intercalating Agents/*chemical synthesis/chemistry
MH  - Lipid Peroxidation
MH  - Lipoxygenase/chemistry
MH  - Lipoxygenase Inhibitors/*chemical synthesis/chemistry
MH  - Models, Molecular
MH  - Molecular Conformation
MH  - Organometallic Compounds/*chemical synthesis/chemistry
MH  - Picrates/chemistry
MH  - Spectrometry, Fluorescence
MH  - Spectrophotometry, Ultraviolet
MH  - Superoxides/chemistry
EDAT- 2012/11/06 06:00
MHDA- 2013/06/01 06:00
CRDT- 2012/11/06 06:00
PHST- 2012/05/31 00:00 [received]
PHST- 2012/09/11 00:00 [revised]
PHST- 2012/09/12 00:00 [accepted]
PHST- 2012/11/06 06:00 [entrez]
PHST- 2012/11/06 06:00 [pubmed]
PHST- 2013/06/01 06:00 [medline]
AID - S0162-0134(12)00301-7 [pii]
AID - 10.1016/j.jinorgbio.2012.09.015 [doi]
PST - ppublish
SO  - J Inorg Biochem. 2013 Jan;118:48-58. doi: 10.1016/j.jinorgbio.2012.09.015. Epub 
      2012 Sep 23.