PMID- 23123667
OWN - NLM
STAT- MEDLINE
DCOM- 20130926
LR  - 20211021
IS  - 1718-4304 (Electronic)
IS  - 0896-8608 (Print)
IS  - 0896-8608 (Linking)
VI  - 33
IP  - 2
DP  - 2013 Mar-Apr
TI  - Ultrafiltration characteristics of glucose polymers with low polydispersity.
PG  - 124-31
LID - 10.3747/pdi.2012.00009 [doi]
AB  - BACKGROUND: Icodextrin, a glucose polymer with a polydispersity [ratio of 
      weight-average molecular weight (Mw) to number-average molecular weight] of 
      approximately 2.6, has been shown, compared with glucose, to provide superior 
      ultrafiltration (UF) efficiency [ratio of UF to carbohydrate (CHO) absorbed] when 
      used as an osmotic agent during a long-dwell peritoneal dialysis exchange. In an 
      experimental rabbit model, we evaluated the effect of Mw on the UF and UF 
      efficiency of glucose polymers with low polydispersity. METHODS: A crossover 
      trial in female New Zealand White rabbits (2.20 - 2.65 kg) with surgically 
      implanted peritoneal catheters evaluated two glucose polymers at nominal 
      concentrations of 7.5 g/dL: a 6K polymer (Mw: 6.4 kDa; polydispersity: 2.3) and a 
      19K polymer (Mw: 18.8 kDa; polydispersity: 2.0). Rabbits were randomized to 
      receive either the 6K (n = 11) or the 19K (n = 12) solution during the first 
      exchange (40 mL/kg body weight). The alternative solution was evaluated in a 
      second exchange 3 days later. During each 4-hour dwell, the UF and total glucose 
      polymer CHO absorbed were determined. RESULTS: The UF was higher for the 6K (p < 
      0.0001) than for the 19K polymer (mean +/- standard deviation: 73.6 +/- 30.8 mL vs. 
      43.0 +/- 20.2 mL), as was the amount of CHO absorbed (42.5% +/- 9.8% vs. 35.7% +/- 
      11.0%, p = 0.021). In spite of higher CHO absorption, an approximately 50% higher 
      (p = 0.029) UF efficiency was achieved with the 6K polymer (28.3 +/- 18.8 mL/g) 
      than with the 19K polymer (19.0 +/- 11.3 mL/g). The results were independent of the 
      order of the experimental exchanges. CONCLUSIONS: Glucose polymers with low 
      polydispersity are effective osmotic agents in a rabbit model. The low-Mw polymer 
      was more effective at generating UF and had a higher UF efficiency, but those 
      results came at the expense of the polymer being more readily absorbed from the 
      peritoneal cavity.
FAU - Leypoldt, John K
AU  - Leypoldt JK
AD  - Medical Products (Renal), Baxter Healthcare Corporation, McGaw Park, Illinois, 
      USA. ken_leypoldt@baxter.com
FAU - Hoff, Catherine M
AU  - Hoff CM
FAU - Piscopo, Dean
AU  - Piscopo D
FAU - Carr, Seraya N
AU  - Carr SN
FAU - Svatek, Jessica M
AU  - Svatek JM
FAU - Holmes, Clifford J
AU  - Holmes CJ
LA  - eng
PT  - Journal Article
DEP - 20121101
PL  - United States
TA  - Perit Dial Int
JT  - Peritoneal dialysis international : journal of the International Society for 
      Peritoneal Dialysis
JID - 8904033
RN  - 0 (Dialysis Solutions)
RN  - 0 (Glucans)
RN  - 2NX48Z0A9G (Icodextrin)
RN  - IY9XDZ35W2 (Glucose)
SB  - IM
MH  - Absorption
MH  - Animals
MH  - Dialysis Solutions/*pharmacokinetics
MH  - Disease Models, Animal
MH  - Female
MH  - Glucans/*pharmacokinetics
MH  - Glucose/*pharmacokinetics
MH  - Icodextrin
MH  - Molecular Weight
MH  - Osmosis/drug effects
MH  - *Peritoneal Dialysis
MH  - Rabbits
MH  - Renal Insufficiency/*metabolism/therapy
MH  - Ultrafiltration
PMC - PMC3598102
EDAT- 2012/11/06 06:00
MHDA- 2013/09/27 06:00
PMCR- 2014/03/01
CRDT- 2012/11/06 06:00
PHST- 2012/11/06 06:00 [entrez]
PHST- 2012/11/06 06:00 [pubmed]
PHST- 2013/09/27 06:00 [medline]
PHST- 2014/03/01 00:00 [pmc-release]
AID - pdi.2012.00009 [pii]
AID - 10.3747/pdi.2012.00009 [doi]
PST - ppublish
SO  - Perit Dial Int. 2013 Mar-Apr;33(2):124-31. doi: 10.3747/pdi.2012.00009. Epub 2012 
      Nov 1.