PMID- 23123886
OWN - NLM
STAT- MEDLINE
DCOM- 20131017
LR  - 20211021
IS  - 1873-7544 (Electronic)
IS  - 0306-4522 (Print)
IS  - 0306-4522 (Linking)
VI  - 239
DP  - 2013 Jun 3
TI  - Testosterone and brain-derived neurotrophic factor interactions in the avian song 
      control system.
PG  - 115-23
LID - S0306-4522(12)00926-8 [pii]
LID - 10.1016/j.neuroscience.2012.09.023 [doi]
AB  - Interaction between steroid sex hormones and brain-derived neurotrophic factor 
      (BDNF) is a common feature of vertebrate brain organization. The avian song 
      control system provides an excellent model for studying such interactions in 
      neural circuits that regulate song, a learned sensorimotor behavior that is often 
      sexually dimorphic and restricted to reproductive contexts. Testosterone (T) and 
      its steroid metabolites interact with BDNF during development of the song system 
      and in adult plasticity, including the addition of newborn neurons to the pallial 
      nucleus HVC and seasonal changes in structure and function of these circuits. T 
      and BDNF interact locally within HVC to influence cell proliferation and 
      survival. This interaction may also occur transsynpatically; T increases the 
      synthesis of BDNF in HVC, and BDNF protein is then released on to postsynaptic 
      cells in the robust nucleus of the arcopallium (RA) where it has trophic effects. 
      The interaction between sex steroids and BDNF is an example of molecular 
      exploitation, with the evolutionarily ancient steroid-receptor complex having 
      been captured by the more recently evolved BDNF. The functional linkage of sex 
      steroids to BDNF may be of adaptive value in regulating the trophic effects of 
      the neurotrophin in sexually dimorphic and reproductively relevant contexts.
CI  - Copyright (c) 2012 IBRO. Published by Elsevier Ltd. All rights reserved.
FAU - Brenowitz, E A
AU  - Brenowitz EA
AD  - Department of Psychology, University of Washington, Seattle, WA 98195-1525, USA. 
      eliotb@u.washington.edu
LA  - eng
GR  - R01 MH053032/MH/NIMH NIH HHS/United States
GR  - R01 NS075331/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Review
DEP - 20121030
PL  - United States
TA  - Neuroscience
JT  - Neuroscience
JID - 7605074
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 3XMK78S47O (Testosterone)
SB  - IM
MH  - Animals
MH  - *Biological Evolution
MH  - Birds/*physiology
MH  - Brain/*physiology
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Neuronal Plasticity/physiology
MH  - Sex Characteristics
MH  - Testosterone/*physiology
MH  - Vocalization, Animal/*physiology
PMC - PMC3612365
MID - NIHMS418665
EDAT- 2012/11/06 06:00
MHDA- 2013/10/18 06:00
PMCR- 2014/06/03
CRDT- 2012/11/06 06:00
PHST- 2012/07/07 00:00 [received]
PHST- 2012/09/07 00:00 [revised]
PHST- 2012/09/11 00:00 [accepted]
PHST- 2012/11/06 06:00 [entrez]
PHST- 2012/11/06 06:00 [pubmed]
PHST- 2013/10/18 06:00 [medline]
PHST- 2014/06/03 00:00 [pmc-release]
AID - S0306-4522(12)00926-8 [pii]
AID - 10.1016/j.neuroscience.2012.09.023 [doi]
PST - ppublish
SO  - Neuroscience. 2013 Jun 3;239:115-23. doi: 10.1016/j.neuroscience.2012.09.023. 
      Epub 2012 Oct 30.