PMID- 23124837
OWN - NLM
STAT- MEDLINE
DCOM- 20130513
LR  - 20211203
IS  - 1943-0264 (Electronic)
IS  - 1943-0264 (Linking)
VI  - 4
IP  - 12
DP  - 2012 Dec 1
TI  - mTOR-dependent cell survival mechanisms.
LID - 10.1101/cshperspect.a008771 [doi]
LID - a008771
AB  - The mechanistic target of rapamycin (mTOR) kinase is a conserved regulator of 
      cell growth, proliferation, and survival. In cells, mTOR is the catalytic subunit 
      of two complexes called mTORC1 and mTORC2, which have distinct upstream 
      regulatory signals and downstream substrates. mTORC1 directly senses cellular 
      nutrient availability while indirectly sensing circulating nutrients through 
      growth factor signaling pathways. Cellular stresses that restrict growth also 
      impinge on mTORC1 activity. mTORC2 is less well understood and appears only to 
      sense growth factors. As an integrator of diverse growth regulatory signals, mTOR 
      evolved to be a central signaling hub for controlling cellular metabolism and 
      energy homoeostasis, and defects in mTOR signaling are important in the 
      pathologies of cancer, diabetes, and aging. Here we discuss mechanisms by which 
      each mTOR complex might regulate cell survival in response to metabolic and other 
      stresses.
FAU - Hung, Chien-Min
AU  - Hung CM
AD  - Program in Molecular Medicine, University of Massachusetts Medical School, 
      Worcester, MA 01605, USA.
FAU - Garcia-Haro, Luisa
AU  - Garcia-Haro L
FAU - Sparks, Cynthia A
AU  - Sparks CA
FAU - Guertin, David A
AU  - Guertin DA
LA  - eng
GR  - R00 CA129613/CA/NCI NIH HHS/United States
GR  - R21 CA161121/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20121201
PL  - United States
TA  - Cold Spring Harb Perspect Biol
JT  - Cold Spring Harbor perspectives in biology
JID - 101513680
RN  - 0 (Multiprotein Complexes)
RN  - 0 (Tuberous Sclerosis Complex 2 Protein)
RN  - 0 (Tumor Suppressor Proteins)
RN  - EC 2.7.11.1 (Mechanistic Target of Rapamycin Complex 1)
RN  - EC 2.7.11.1 (Mechanistic Target of Rapamycin Complex 2)
RN  - EC 2.7.11.1 (TOR Serine-Threonine Kinases)
SB  - IM
MH  - Animals
MH  - Autophagy/*physiology
MH  - Cell Growth Processes/*physiology
MH  - Cell Survival/*physiology
MH  - Humans
MH  - Mechanistic Target of Rapamycin Complex 1
MH  - Mechanistic Target of Rapamycin Complex 2
MH  - Multiprotein Complexes/*metabolism
MH  - Neoplasms/drug therapy/*metabolism
MH  - Signal Transduction/*physiology
MH  - TOR Serine-Threonine Kinases/*metabolism
MH  - Tuberous Sclerosis Complex 2 Protein
MH  - Tumor Suppressor Proteins/metabolism
PMC - PMC3504431
EDAT- 2012/11/06 06:00
MHDA- 2013/05/15 06:00
PMCR- 2014/12/01
CRDT- 2012/11/06 06:00
PHST- 2012/11/06 06:00 [entrez]
PHST- 2012/11/06 06:00 [pubmed]
PHST- 2013/05/15 06:00 [medline]
PHST- 2014/12/01 00:00 [pmc-release]
AID - cshperspect.a008771 [pii]
AID - a008771 [pii]
AID - 10.1101/cshperspect.a008771 [doi]
PST - epublish
SO  - Cold Spring Harb Perspect Biol. 2012 Dec 1;4(12):a008771. doi: 
      10.1101/cshperspect.a008771.