PMID- 23124884
OWN - NLM
STAT- MEDLINE
DCOM- 20130524
LR  - 20211021
IS  - 2095-0225 (Electronic)
IS  - 2095-0217 (Linking)
VI  - 6
IP  - 4
DP  - 2012 Dec
TI  - Tramadol reinforces antidepressant effects of ketamine with increased levels of 
      brain-derived neurotrophic factor and tropomyosin-related kinase B in rat 
      hippocampus.
PG  - 411-5
LID - 10.1007/s11684-012-0226-2 [doi]
AB  - Ketamine exerts rapid and robust antidepressant properties in both animal models 
      and depressed patients and tramadol possesses potential antidepressant effects. 
      Brain-derived neurotrophic factor (BDNF) is an important biomarker for mood 
      disorders and tropomyosin-related kinase B (TrkB) is a high affinity catalytic 
      receptor for BDNF.We hypothesized that tramadol pretreatment might reinforce 
      ketamine-elicited antidepressant effects with significant changes in hippocampal 
      BDNF and TrkB levels in rats. Immobility time of rats receiving different 
      treatment in the forced swimming test (FST) was observed. Levels of BDNF and TrkB 
      in hippocampus were measured by enzyme linked immunosorbent assay. Results showed 
      that tramadol (5 mg/kg) administrated alone neither elicited antidepressant 
      effects nor altered BDNF or TrkB level. However, pretreatment with tramadol (5 
      mg/kg) enhanced the ketamine (10 mg/kg) -elicited antidepressant effects and 
      upregulated the BDNF and TrkB levels in hippocampus. In conclusion, tramadol 
      pretreatment reinforces the ketamine-elicited antidepressant effects, which is 
      associated with the increased levels of BDNF and TrkB in rat hippocampus.
FAU - Yang, Chun
AU  - Yang C
AD  - Department of Anesthesiology, Jinling Hospital, School of Medicine, Nanjing 
      University, Nanjing 210002, China.
FAU - Li, Xiaomin
AU  - Li X
FAU - Wang, Nan
AU  - Wang N
FAU - Xu, Shixia
AU  - Xu S
FAU - Yang, Jianjun
AU  - Yang J
FAU - Zhou, Zhiqiang
AU  - Zhou Z
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121103
PL  - China
TA  - Front Med
JT  - Frontiers of medicine
JID - 101549428
RN  - 0 (Analgesics, Opioid)
RN  - 0 (Antidepressive Agents)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 39J1LGJ30J (Tramadol)
RN  - 690G0D6V8H (Ketamine)
RN  - EC 2.7.- (Protein Kinases)
RN  - EC 2.7.11.28 (tropomyosin kinase)
SB  - IM
MH  - Analgesics, Opioid/pharmacology
MH  - Animals
MH  - Antidepressive Agents/pharmacology
MH  - Brain-Derived Neurotrophic Factor/*drug effects
MH  - Drug Synergism
MH  - Hippocampus/*drug effects
MH  - Ketamine/*pharmacology
MH  - Male
MH  - Models, Animal
MH  - Protein Kinases/*pharmacology
MH  - Rats
MH  - Rats, Wistar
MH  - Tramadol/*pharmacology
EDAT- 2012/11/06 06:00
MHDA- 2013/05/28 06:00
CRDT- 2012/11/06 06:00
PHST- 2011/11/15 00:00 [received]
PHST- 2012/09/18 00:00 [accepted]
PHST- 2012/11/06 06:00 [entrez]
PHST- 2012/11/06 06:00 [pubmed]
PHST- 2013/05/28 06:00 [medline]
AID - 10.1007/s11684-012-0226-2 [doi]
PST - ppublish
SO  - Front Med. 2012 Dec;6(4):411-5. doi: 10.1007/s11684-012-0226-2. Epub 2012 Nov 3.