PMID- 23125445
OWN - NLM
STAT- MEDLINE
DCOM- 20130228
LR  - 20211021
IS  - 1537-6613 (Electronic)
IS  - 0022-1899 (Print)
IS  - 0022-1899 (Linking)
VI  - 207
IP  - 2
DP  - 2013 Jan 15
TI  - Schistosoma mansoni infection in preschool-aged children: development of 
      immunoglobulin E and immunoglobulin G4 responses to parasite allergen-like 
      proteins.
PG  - 362-6
LID - 10.1093/infdis/jis676 [doi]
AB  - Specific immunoglobulin E (IgE) responses are upregulated during chronic 
      schistosome infection and during allergy. These responses are tightly regulated 
      during schistosomiasis. We have previously shown that IgE regulation depends on 
      the extent and length of exposure to individual parasite allergen-like proteins. 
      Here we compare the development of IgE and immunoglobulin G4 (IgG(4)) responses 
      to the differentially expressed allergen-like proteins SmTAL1 and SmTAL2 among 
      preschool-aged children from 2 villages with different levels of Schistosoma 
      mansoni transmission. We found a lack of SmTAL1 responsiveness among all 
      children, but evidence for IgG(4)-dependent IgE-SmTAL2 desensitization in both 
      villages, occurring earlier among children from the village where the level of 
      transmission was greater. Findings provide insights into the development and 
      regulation of allergic-type immune responses.
FAU - Pinot de Moira, Angela
AU  - Pinot de Moira A
AD  - Department of Pathology, University of Cambridge, United Kingdom. acp44@cam.ac.uk
FAU - Sousa-Figueiredo, Jose C
AU  - Sousa-Figueiredo JC
FAU - Jones, Frances M
AU  - Jones FM
FAU - Fitzsimmons, Colin M
AU  - Fitzsimmons CM
FAU - Betson, Martha
AU  - Betson M
FAU - Kabatereine, Narcis B
AU  - Kabatereine NB
FAU - Stothard, J Russell
AU  - Stothard JR
FAU - Dunne, David W
AU  - Dunne DW
LA  - eng
GR  - 083931/Z/07/Z/Wellcome Trust/United Kingdom
GR  - WT085440MA/Wellcome Trust/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121102
PL  - United States
TA  - J Infect Dis
JT  - The Journal of infectious diseases
JID - 0413675
RN  - 0 (Allergens)
RN  - 0 (Helminth Proteins)
RN  - 0 (Immunoglobulin G)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adult
MH  - Allergens/*immunology
MH  - Animals
MH  - Child, Preschool
MH  - Female
MH  - Helminth Proteins/*immunology
MH  - Humans
MH  - Immunoglobulin E/*blood
MH  - Immunoglobulin G/*blood
MH  - Infant
MH  - Schistosoma mansoni/*immunology
MH  - Schistosomiasis mansoni/*immunology/parasitology/transmission
MH  - Uganda
PMC - PMC3532835
EDAT- 2012/11/06 06:00
MHDA- 2013/03/01 06:00
PMCR- 2012/11/02
CRDT- 2012/11/06 06:00
PHST- 2012/11/06 06:00 [entrez]
PHST- 2012/11/06 06:00 [pubmed]
PHST- 2013/03/01 06:00 [medline]
PHST- 2012/11/02 00:00 [pmc-release]
AID - jis676 [pii]
AID - 10.1093/infdis/jis676 [doi]
PST - ppublish
SO  - J Infect Dis. 2013 Jan 15;207(2):362-6. doi: 10.1093/infdis/jis676. Epub 2012 Nov 
      2.