PMID- 23127751
OWN - NLM
STAT- MEDLINE
DCOM- 20130314
LR  - 20220310
IS  - 1879-1891 (Electronic)
IS  - 0002-9394 (Print)
IS  - 0002-9394 (Linking)
VI  - 155
IP  - 2
DP  - 2013 Feb
TI  - Normative reference ranges for the retinal nerve fiber layer, macula, and retinal 
      layer thicknesses in children.
PG  - 354-360.e1
LID - S0002-9394(12)00581-8 [pii]
LID - 10.1016/j.ajo.2012.08.010 [doi]
AB  - PURPOSE: To establish a normative database of peripapillary retinal nerve fiber 
      layer (RNFL) thickness, macular thickness, and retinal layer thickness in healthy 
      North American children, using spectral-domain optical coherence tomography (SD 
      OCT). DESIGN: Prospective cross-sectional study. METHODS: This institutional 
      study enrolled 83 healthy children (aged 5-15 years) as volunteer research 
      subjects at the Retina Foundation of the Southwest (Dallas, Texas); all had 
      normal visual acuity. Imaging was accomplished with the Spectralis SD OCT. 
      Peripapillary RNFL thickness and macular thickness were assessed for 1 eye of 
      each child using the Heidelberg Spectralis SD OCT software. Thicknesses of 
      individual retinal layers and layer combinations were assessed using custom 
      software to segment the line scans obtained with the Spectralis SD OCT. RESULTS: 
      Average global peripapillary RNFL thickness was 107.6 +/- 1.2 mum and average 
      central subfield macular thickness was 271.2 +/- 2.0 mum. Peripapillary RNFL 
      thickness was thicker than has been reported in adults, particularly the superior 
      and inferior sectors, and central subfield macular thickness was significantly 
      correlated with age. While the thickness of most retinal layers was comparable 
      with those of adults, the outer segment layer was 36% thinner in children than in 
      adults. CONCLUSIONS: SD OCT can be used to assess peripapillary RNFL thickness, 
      macular thickness, and retinal layer thickness in children as young as 5 years. 
      Pediatric means and normative reference ranges are provided for each measurement. 
      The values presented herein can be used as a standard with which to compare those 
      of children suspected of having retinal or optic nerve abnormalities.
CI  - Copyright (c) 2013 Elsevier Inc. All rights reserved.
FAU - Yanni, Susan E
AU  - Yanni SE
AD  - Retina Foundation of the Southwest, Dallas, Texas 75231-0920, USA. 
      susan.e.yanni@gmail.com
FAU - Wang, Jingyun
AU  - Wang J
FAU - Cheng, Christina S
AU  - Cheng CS
FAU - Locke, Kelly I
AU  - Locke KI
FAU - Wen, Yuquan
AU  - Wen Y
FAU - Birch, David G
AU  - Birch DG
FAU - Birch, Eileen E
AU  - Birch EE
LA  - eng
GR  - R01 EY009076/EY/NEI NIH HHS/United States
GR  - R01 EY022313/EY/NEI NIH HHS/United States
GR  - EY09076/EY/NEI NIH HHS/United States
GR  - EY022313/EY/NEI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20121103
PL  - United States
TA  - Am J Ophthalmol
JT  - American journal of ophthalmology
JID - 0370500
SB  - IM
MH  - Adolescent
MH  - Child
MH  - Child, Preschool
MH  - Cross-Sectional Studies
MH  - Female
MH  - Humans
MH  - Male
MH  - *Nerve Fibers
MH  - Optic Disk/*anatomy & histology
MH  - Prospective Studies
MH  - Reference Values
MH  - Retina/*anatomy & histology
MH  - Retinal Ganglion Cells/*cytology
MH  - Tomography, Optical Coherence
MH  - Visual Acuity/physiology
PMC - PMC3545013
MID - NIHMS404499
EDAT- 2012/11/07 06:00
MHDA- 2013/03/15 06:00
PMCR- 2014/02/01
CRDT- 2012/11/07 06:00
PHST- 2012/07/13 00:00 [received]
PHST- 2012/08/14 00:00 [revised]
PHST- 2012/08/16 00:00 [accepted]
PHST- 2012/11/07 06:00 [entrez]
PHST- 2012/11/07 06:00 [pubmed]
PHST- 2013/03/15 06:00 [medline]
PHST- 2014/02/01 00:00 [pmc-release]
AID - S0002-9394(12)00581-8 [pii]
AID - 10.1016/j.ajo.2012.08.010 [doi]
PST - ppublish
SO  - Am J Ophthalmol. 2013 Feb;155(2):354-360.e1. doi: 10.1016/j.ajo.2012.08.010. Epub 
      2012 Nov 3.