PMID- 23127872
OWN - NLM
STAT- MEDLINE
DCOM- 20131126
LR  - 20180515
IS  - 1095-7103 (Electronic)
IS  - 0021-9797 (Linking)
VI  - 392
DP  - 2013 Feb 15
TI  - Synthesis, self-assembly, and pH-responsive behavior of (photo-crosslinked) star 
      amphiphilic triblock copolymer.
PG  - 141-150
LID - S0021-9797(12)01130-7 [pii]
LID - 10.1016/j.jcis.2012.08.076 [doi]
AB  - Conventional polymeric micelles employed as drug carriers suffer from the 
      drawback of disaggregation when diluted into body fluids, giving rise to 
      premature release of drugs. In this work, cinnamate was chosen as a crosslinker 
      to overcome this issue and regulate pH response. A series of photo-crosslinkable 
      star amphiphilic triblock copolymers, star 
      poly(epsilon-caprolactone)-b-poly(2-cinnamoyloxyethyl 
      methacrylate)-b-poly(2-(dimethylamino)ethyl methacrylate) 
      (SPCL-b-PCEMA-b-PDMAEMA), were prepared by combination of stepwise reversible 
      addition-fragment chain transfer (RAFT) polymerization and carbodiimide-mediated 
      coupling reaction. These star amphiphilic copolymers could self-assemble into 
      core-shell-corona micelles. Facile photo crosslinking of the micelles was carried 
      out via UV irradiation. The crosslinked micelles showed an improved stability 
      determined by critical micelle concentration (CMC). The degree of photo 
      crosslinking was easily regulated by tuning UV irradiation time, and the 
      hydrodynamic diameters (D(h)) decreased with increasing degree of photo 
      crosslinking. The pH responses of micelles were investigated by dynamic light 
      scattering (DLS), indicating pH-induced swelling-shrinking behavior. For 
      photo-crosslinked micelle, its capability of swelling-shrinking weakened with 
      increasing crosslinking degree, suggesting that pH response was controlled by 
      crosslinking density. This novel photo-crosslinked micelle system with adjustable 
      pH response was expected to have potential as drug carriers for controlled 
      release.
CI  - Copyright (c) 2012 Elsevier Inc. All rights reserved.
FAU - Bian, Qingqing
AU  - Bian Q
AD  - Shanghai Key Laboratory of Advanced Polymeric Materials, Key Laboratory for 
      Ultrafine Materials of Ministry of Education, School of Materials Science and 
      Engineering, East China University of Science and Technology, Shanghai 200237, 
      China.
FAU - Xiao, Yan
AU  - Xiao Y
AD  - Shanghai Key Laboratory of Advanced Polymeric Materials, Key Laboratory for 
      Ultrafine Materials of Ministry of Education, School of Materials Science and 
      Engineering, East China University of Science and Technology, Shanghai 200237, 
      China. Electronic address: yxiao@ecust.edu.cn.
FAU - Zhou, Chen
AU  - Zhou C
AD  - Shanghai Key Laboratory of Advanced Polymeric Materials, Key Laboratory for 
      Ultrafine Materials of Ministry of Education, School of Materials Science and 
      Engineering, East China University of Science and Technology, Shanghai 200237, 
      China.
FAU - Lang, Meidong
AU  - Lang M
AD  - Shanghai Key Laboratory of Advanced Polymeric Materials, Key Laboratory for 
      Ultrafine Materials of Ministry of Education, School of Materials Science and 
      Engineering, East China University of Science and Technology, Shanghai 200237, 
      China. Electronic address: mdlang@ecust.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121016
PL  - United States
TA  - J Colloid Interface Sci
JT  - Journal of colloid and interface science
JID - 0043125
RN  - 0 (Cross-Linking Reagents)
RN  - 0 (Polymers)
SB  - IM
MH  - Cross-Linking Reagents/*chemical synthesis/chemistry
MH  - Hydrogen-Ion Concentration
MH  - Molecular Structure
MH  - Photochemical Processes
MH  - Polymers/*chemical synthesis/chemistry
EDAT- 2012/11/07 06:00
MHDA- 2013/12/16 06:00
CRDT- 2012/11/07 06:00
PHST- 2012/05/02 00:00 [received]
PHST- 2012/08/10 00:00 [revised]
PHST- 2012/08/18 00:00 [accepted]
PHST- 2012/11/07 06:00 [entrez]
PHST- 2012/11/07 06:00 [pubmed]
PHST- 2013/12/16 06:00 [medline]
AID - S0021-9797(12)01130-7 [pii]
AID - 10.1016/j.jcis.2012.08.076 [doi]
PST - ppublish
SO  - J Colloid Interface Sci. 2013 Feb 15;392:141-150. doi: 
      10.1016/j.jcis.2012.08.076. Epub 2012 Oct 16.