PMID- 23128460
OWN - NLM
STAT- MEDLINE
DCOM- 20130926
LR  - 20231110
IS  - 1648-9144 (Electronic)
IS  - 1010-660X (Print)
IS  - 1010-660X (Linking)
VI  - 48
IP  - 8
DP  - 2012
TI  - Does matrix metalloproteinase-3 polymorphism play a role in age-related macular 
      degeneration in patients with myocardial infarction?
PG  - 404-9
AB  - OBJECTIVE: The aim of our study was to determine if the genotype of the matrix 
      metalloproteinase-3 (MMP-3) gene might carry the risk of age-related macular 
      degeneration (ARMD) in patients with myocardial infarction. MATERIAL AND METHODS: 
      A total of 499 patients with an acute myocardial infarction or with a history of 
      myocardial infarction were enrolled into the study. They were subdivided into 2 
      groups: 273 patients with ARMD and 226 patients without ARMD. The control group 
      comprised 560 persons from a random sample of the Lithuanian population. DNA was 
      analyzed using real-time polymerase chain reaction to genotype polymorphism 5A/6A 
      at a position -1171 of the MMP-3 gene promoter. RESULTS: Of the 499 patients with 
      myocardial infarction, 47% had early-stage ARMD. The patients with ARMD were 
      older than the patients in the group without ARMD (62.1+/-10.8 vs. 59.6+/-11.1, 
      P<0.01). The analysis of MMP-3 gene polymorphism did not reveal any differences 
      in the distribution of 5A/5A, 5A/6A, and 6A/6A genotypes between the ARMD group, 
      non-ARMD group, and the control group (24.2%, 52.5%, and 23.3% in the ARMD group; 
      28.7%, 51.9%, and 19.4% in non-ARMD group; and 25.7%, 49.3% and 25.0%, in the 
      control group, respectively). CONCLUSIONS: MMP-3 gene polymorphism had no 
      predominant effect on the development of ARMD in patients with myocardial 
      infarction.
FAU - Liutkeviciene, Rasa
AU  - Liutkeviciene R
AD  - Department of Ophthalmology, Medical Academy, Lithuanian University of Health 
      Sciences, Kaunas, Lithuania. rliutkeviciene@gmail.com
FAU - Zaliaduonyte-Peksiene, Diana
AU  - Zaliaduonyte-Peksiene D
FAU - Zaliuniene, Dalia
AU  - Zaliuniene D
FAU - Gustiene, Olivija
AU  - Gustiene O
FAU - Jasinskas, Vytautas
AU  - Jasinskas V
FAU - Lesauskaite, Vaiva
AU  - Lesauskaite V
FAU - Tamosiunas, Abdonas
AU  - Tamosiunas A
FAU - Zaliunas, Remigijus
AU  - Zaliunas R
LA  - eng
GR  - 1R01 AG23522-01/AG/NIA NIH HHS/United States
GR  - 064947/Z/01/Z/WT_/Wellcome Trust/United Kingdom
GR  - R01 AG023522/AG/NIA NIH HHS/United States
GR  - 081081/WT_/Wellcome Trust/United Kingdom
GR  - WT_/Wellcome Trust/United Kingdom
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - Switzerland
TA  - Medicina (Kaunas)
JT  - Medicina (Kaunas, Lithuania)
JID - 9425208
RN  - EC 3.4.24.17 (Matrix Metalloproteinase 3)
SB  - IM
MH  - Aged
MH  - Female
MH  - Humans
MH  - Lithuania/epidemiology
MH  - Macular Degeneration/*epidemiology/*genetics
MH  - Male
MH  - Matrix Metalloproteinase 3/*genetics
MH  - Middle Aged
MH  - Myocardial Infarction/*epidemiology
MH  - Polymorphism, Genetic
PMC - PMC3968398
MID - EMS57414
OID - NLM: EMS57414
EDAT- 2012/11/07 06:00
MHDA- 2013/09/27 06:00
PMCR- 2014/03/28
CRDT- 2012/11/07 06:00
PHST- 2012/11/07 06:00 [entrez]
PHST- 2012/11/07 06:00 [pubmed]
PHST- 2013/09/27 06:00 [medline]
PHST- 2014/03/28 00:00 [pmc-release]
AID - 1208-04e [pii]
PST - ppublish
SO  - Medicina (Kaunas). 2012;48(8):404-9.