PMID- 23128606
OWN - NLM
STAT- MEDLINE
DCOM- 20131028
LR  - 20180816
IS  - 1421-9891 (Electronic)
IS  - 1022-6877 (Linking)
VI  - 19
IP  - 2
DP  - 2013
TI  - Serum brain-derived neurotrophic factor and nerve growth factor concentrations 
      change after alcohol withdrawal: preliminary data of a case-control comparison.
PG  - 98-104
LID - 10.1159/000342334 [doi]
AB  - BACKGROUND: Brain-derived neurotrophic factor (BDNF) and nerve growth factor 
      (NGF) are involved in neuroadaptation and foster survival of central and 
      peripheral neurons. In this study, we addressed the question whether BDNF and NGF 
      serum concentrations change during subacute alcohol withdrawal in patients with 
      alcohol dependence compared to healthy controls. METHODS: Fifteen patients (age 
      48.6 +/- 7 years) and 15 healthy age-matched controls (age 48.8 +/- 7 years) 
      participated consecutively in a 2-week withdrawal study. RESULTS: Mean BDNF 
      levels (7.8 ng/ml, IQR = 4.4-10.7 vs. 16.5 ng/ml, IQR = 13.9-25.6; Z = -3.8, p < 
      0.0001) and NGF levels (5.8 pg/ml, IQR = 3.8-13.0 vs. 18.4 pg/ml, IQR = 
      10.9-25.1; Z = -2.5, p = 0.012) were significantly decreased in alcohol-dependent 
      subjects when compared to healthy matched controls. NGF concentrations decreased 
      significantly from day 3 to day 14 (Z = -2.36; p = 0.019). Mean BDNF 
      concentrations showed a tendency to increase after withdrawal from day 3 to day 
      14 (Z = 1.7; p = 0.078). CONCLUSION: Decreased NGF and BDNF concentrations in 
      patients suffering from alcohol dependence, which stabilize after physical 
      withdrawal, are in line with withdrawal symptoms and neurological risk factors. 
      In turn, increase of BDNF after acute withdrawal might be connected to 
      neurobiological and behavioral stabilization.
CI  - Copyright (c) 2012 S. Karger AG, Basel.
FAU - Kohler, Stephan
AU  - Kohler S
AD  - Department of Psychiatry and Psychotherapy, Charite Medicine Berlin, Campus 
      Mitte, Berlin, Germany.
FAU - Klimke, Sebastian
AU  - Klimke S
FAU - Hellweg, Rainer
AU  - Hellweg R
FAU - Lang, Undine E
AU  - Lang UE
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121101
PL  - Switzerland
TA  - Eur Addict Res
JT  - European addiction research
JID - 9502920
RN  - 0 (Biomarkers)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (NGF protein, human)
RN  - 7171WSG8A2 (BDNF protein, human)
RN  - 9061-61-4 (Nerve Growth Factor)
SB  - IM
MH  - Adult
MH  - Alcoholism/*blood/diagnosis/epidemiology
MH  - Biomarkers/blood
MH  - Brain-Derived Neurotrophic Factor/antagonists & inhibitors/biosynthesis/*blood
MH  - Case-Control Studies
MH  - Databases, Factual
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Nerve Growth Factor/antagonists & inhibitors/biosynthesis/*blood
MH  - Substance Withdrawal Syndrome/*blood/diagnosis/epidemiology
MH  - *Temperance
EDAT- 2012/11/07 06:00
MHDA- 2013/10/29 06:00
CRDT- 2012/11/07 06:00
PHST- 2012/04/15 00:00 [received]
PHST- 2012/08/05 00:00 [accepted]
PHST- 2012/11/07 06:00 [entrez]
PHST- 2012/11/07 06:00 [pubmed]
PHST- 2013/10/29 06:00 [medline]
AID - 000342334 [pii]
AID - 10.1159/000342334 [doi]
PST - ppublish
SO  - Eur Addict Res. 2013;19(2):98-104. doi: 10.1159/000342334. Epub 2012 Nov 1.