PMID- 23129267
OWN - NLM
STAT- MEDLINE
DCOM- 20130812
LR  - 20211021
IS  - 1098-1063 (Electronic)
IS  - 1050-9631 (Print)
IS  - 1050-9631 (Linking)
VI  - 23
IP  - 3
DP  - 2013 Mar
TI  - Intrinsic connectivity between the hippocampus, nucleus accumbens, and ventral 
      tegmental area in humans.
PG  - 187-92
LID - 10.1002/hipo.22077 [doi]
AB  - Recent studies suggest that memory formation in the hippocampus is modulated by 
      the motivational significance of events, allowing past experience to adaptively 
      guide behavior. The effects of motivation on memory are thought to depend on 
      interactions between the hippocampus, the ventral tegmental area (VTA), and the 
      nucleus accumbens (NAcc). Indeed, animal studies reveal anatomical pathways for 
      circuit-level interaction between these regions. However, a homologue circuit 
      connectivity in humans remains to be shown. We characterized this circuitry in 
      humans by exploiting spontaneous low-frequency modulations in the fMRI signal 
      (termed resting-state functional connectivity), which are thought to reflect 
      functionally related regions and their organization into functional networks in 
      the brain. We examined connectivity in this network across two datasets 
      (hi-resolution, n = 100; standard resolution, n = 894). Results reveal convergent 
      connectivity between the hippocampus, and both the NAcc and the VTA centered on 
      ventral regions in the body of the hippocampus. Additionally, we found individual 
      differences in the strength of connectivity within this network. Together, these 
      results provide a novel task-independent characterization of circuitry underlying 
      interactions between the hippocampus, NAcc, and VTA and provide a framework with 
      which to understand how connectivity might reflect and constrain the effects of 
      motivation on memory.
CI  - Copyright (c) 2012 Wiley Periodicals, Inc.
FAU - Kahn, I
AU  - Kahn I
AD  - Department of Physiology and Biophysics, Ruth and Bruce Rappaport Faculty of 
      Medicine and Rappaport Institute, Technion-Israel Institute of Technology, Haifa, 
      Israel. kahn@technion.ac.il
FAU - Shohamy, D
AU  - Shohamy D
LA  - eng
GR  - P41 RR009784/RR/NCRR NIH HHS/United States
GR  - R03 DA026957/DA/NIDA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20121105
PL  - United States
TA  - Hippocampus
JT  - Hippocampus
JID - 9108167
SB  - IM
MH  - Adult
MH  - Brain Mapping
MH  - Female
MH  - Hippocampus/*anatomy & histology/physiology
MH  - Humans
MH  - Image Interpretation, Computer-Assisted
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Memory/physiology
MH  - Neural Pathways/*anatomy & histology/physiology
MH  - Nucleus Accumbens/*anatomy & histology/physiology
MH  - Rest/physiology
MH  - Ventral Tegmental Area/*anatomy & histology/physiology
PMC - PMC4118056
MID - NIHMS598202
EDAT- 2012/11/07 06:00
MHDA- 2013/08/13 06:00
PMCR- 2014/08/01
CRDT- 2012/11/07 06:00
PHST- 2012/08/30 00:00 [accepted]
PHST- 2012/11/07 06:00 [entrez]
PHST- 2012/11/07 06:00 [pubmed]
PHST- 2013/08/13 06:00 [medline]
PHST- 2014/08/01 00:00 [pmc-release]
AID - 10.1002/hipo.22077 [doi]
PST - ppublish
SO  - Hippocampus. 2013 Mar;23(3):187-92. doi: 10.1002/hipo.22077. Epub 2012 Nov 5.