PMID- 23129644
OWN - NLM
STAT- MEDLINE
DCOM- 20130129
LR  - 20240327
IS  - 1091-6490 (Electronic)
IS  - 0027-8424 (Print)
IS  - 0027-8424 (Linking)
VI  - 109
IP  - 47
DP  - 2012 Nov 20
TI  - Genetic evidence that brain-derived neurotrophic factor mediates competitive 
      interactions between individual cortical neurons.
PG  - 19456-61
LID - 10.1073/pnas.1206492109 [doi]
AB  - Brain-derived neurotrophic factor (BDNF) is a secreted protein important for 
      development and function of neocortical circuitry. Although it is well 
      established that BDNF contributes to the sculpting of dendrite structure and 
      modulation of synapse strength, the range and directionality of BDNF signaling 
      underlying these functions are incompletely understood. To gain insights into the 
      role of BDNF at the level of individual neurons, we tested the cell-autonomous 
      requirements for Bdnf in visual cortical layer 2/3 neurons. We found that the 
      number of functional Bdnf alleles a neuron carries relative to the prevailing 
      genotype determines its density of dendritic spines, the structures at which most 
      excitatory synapses are made. This requirement for Bdnf exists both during 
      postnatal development and in adulthood, suggesting that the amount of BDNF a 
      neuron is capable of producing determines its success in ongoing competition in 
      the environment of the neocortex. Our results suggest that BDNF may perform a 
      long-sought function for a secreted growth factor in mediating the competitive 
      events that shape individual neurons and their circuits.
FAU - English, Christopher N
AU  - English CN
AD  - Department of Molecular, Cellular, and Developmental Biology, University of 
      Colorado, Boulder, CO 80309, USA.
FAU - Vigers, Alison J
AU  - Vigers AJ
FAU - Jones, Kevin R
AU  - Jones KR
LA  - eng
GR  - R01 EY014998/EY/NEI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20121105
PL  - United States
TA  - Proc Natl Acad Sci U S A
JT  - Proceedings of the National Academy of Sciences of the United States of America
JID - 7505876
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Aging/genetics/metabolism
MH  - Animals
MH  - Animals, Newborn
MH  - Brain-Derived Neurotrophic Factor/*genetics/metabolism
MH  - Dendritic Spines/metabolism
MH  - Gene Expression Regulation
MH  - Genetic Loci
MH  - Genotype
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mutation/genetics
MH  - Neurons/cytology/*metabolism
MH  - Visual Cortex/*cytology
PMC - PMC3511098
COIS- The authors declare no conflict of interest.
EDAT- 2012/11/07 06:00
MHDA- 2013/01/30 06:00
PMCR- 2013/05/20
CRDT- 2012/11/07 06:00
PHST- 2012/11/07 06:00 [entrez]
PHST- 2012/11/07 06:00 [pubmed]
PHST- 2013/01/30 06:00 [medline]
PHST- 2013/05/20 00:00 [pmc-release]
AID - 1206492109 [pii]
AID - 201206492 [pii]
AID - 10.1073/pnas.1206492109 [doi]
PST - ppublish
SO  - Proc Natl Acad Sci U S A. 2012 Nov 20;109(47):19456-61. doi: 
      10.1073/pnas.1206492109. Epub 2012 Nov 5.