PMID- 23130104
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121212
LR  - 20211021
IS  - 2045-8940 (Electronic)
IS  - 2045-8932 (Print)
IS  - 2045-8932 (Linking)
VI  - 2
IP  - 3
DP  - 2012 Jul
TI  - An Australian tertiary referral center experience of the management of chronic 
      thromboembolic pulmonary hypertension.
PG  - 359-64
LID - 10.4103/2045-8932.101649 [doi]
AB  - The objective of this study was to report the outcome of pulmonary endarterectomy 
      (PEA) surgery performed for chronic thromboembolic pulmonary hypertension (CTEPH) 
      at a single tertiary center. The prospective study consisted of 35 patients with 
      surgically amenable CTEPH undergoing PEA between September 2004 and September 
      2010. The main outcome measures were Functional (New York Heart Association 
      [NYHA] class, 6-Minute Walk Distance), hemodynamic (echocardiography, right heart 
      catheterization, and cardiac MRI), and outcome data (morbidity and mortality). 
      Following PEA, there were significant improvements in NYHA class (pre 2.9+/-0.7 vs. 
      post 1.3+/-0.5, P < 0.0001), right ventricular systolic pressure (pre 77.4+/-24.8 
      mmHg vs. post 45.1+/-24.9 mmHg, P = 0.0005), 6-Minute Walk Distance (pre 
      419.6+/-109.4 m vs. post 521.6+/-83.5 m, P = 0.0017), mean pulmonary artery pressure 
      (pre 41.8+/-15.3 mmHg vs. post 24.7+/-8.8 mmHg, P = 0.0006), and cardiac MRI indices 
      (end diastolic volume pre 213.8+/-49.2 mL vs. post 148.1+/-34.5 mL, P < 0.0001; 
      ejection fraction pre 40.7+/-9.8 mL vs. post 48.1+/-8.9 mL, P = 0.0069). The mean 
      cardiopulmonary bypass time was 258.77+/-26.16 min, with a mean circulatory arrest 
      time of 43.83+/-28.78 min, a mean ventilation time of 4.7+/-7.93 days (range 
      0.2-32.7), and a mean intensive care unit stay of 7.22+/-8.71 days (range 
      1.1-33.8). Complications included reperfusion lung injury (20%), persistent 
      pulmonary hypertension (17.1%), slow respiratory wean (25.7%), pericardial 
      effusion (11.4%), and cardiac tamponade (5.7%). 1-year mortality post-procedure 
      was 11.4%. Pulmonary endarterectomy can be performed safely with relatively low 
      mortality.
FAU - Maliyasena, Videshinie A
AU  - Maliyasena VA
AD  - Queensland Centre for Pulmonary Transplantation and Vascular Diseases, The Prince 
      Charles Hospital, Brisbane, Australia.
FAU - Hopkins, Peter M A
AU  - Hopkins PM
FAU - Thomson, Bruce M
AU  - Thomson BM
FAU - Dunning, John
AU  - Dunning J
FAU - Wall, Douglas A
AU  - Wall DA
FAU - Ng, Benjamin J
AU  - Ng BJ
FAU - McNeil, Keith D
AU  - McNeil KD
FAU - Mullany, Daniel
AU  - Mullany D
FAU - Kermeen, Fiona D
AU  - Kermeen FD
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Pulm Circ
JT  - Pulmonary circulation
JID - 101557243
PMC - PMC3487304
OTO - NOTNLM
OT  - chronic thromboembolic pulmonary hypertension
OT  - pulmonary artery sarcoma
OT  - pulmonary endarterectomy
OT  - pulmonary vascular resistance
OT  - pulmonary vasodilator therapy
COIS- Conflict of Interest: None declared.
EDAT- 2012/11/07 06:00
MHDA- 2012/11/07 06:01
PMCR- 2012/07/01
CRDT- 2012/11/07 06:00
PHST- 2012/11/07 06:00 [entrez]
PHST- 2012/11/07 06:00 [pubmed]
PHST- 2012/11/07 06:01 [medline]
PHST- 2012/07/01 00:00 [pmc-release]
AID - PC-2-359 [pii]
AID - 10.4103/2045-8932.101649 [doi]
PST - ppublish
SO  - Pulm Circ. 2012 Jul;2(3):359-64. doi: 10.4103/2045-8932.101649.