PMID- 23130899
OWN - NLM
STAT- MEDLINE
DCOM- 20130712
LR  - 20201023
IS  - 1802-9973 (Electronic)
IS  - 0862-8408 (Linking)
VI  - 61
IP  - Suppl 2
DP  - 2012
TI  - Behavioral and antinociceptive effects of different psychostimulant drugs in 
      prenatally methamphetamine-exposed rats.
PG  - S139-47
AB  - Prenatal exposure to methamphetamine (METH) increases nociceptive sensitivity in 
      adult rats. As the strong analgesics have high abuse potential and drugs of abuse 
      are known to have analgesic properties, the aim was to study analgesic effect of 
      different psychostimulants in control and prenatally METH-exposed rats. Latencies 
      of withdrawal reflexes of hind limbs and the tail on thermal nociceptive stimuli 
      were repeatedly measured in 15-min intervals after the application of 5 mg/kg 
      s.c. of amphetamine (AMPH), methamphetamine (METH), cocaine (COC), 
      3,4-methylenedioxymethamphetamine (MDMA) or morphine (MOR). In all groups, AMPH 
      induced on hind limbs stronger analgesia than METH and MDMA whereas COC and MOR 
      were practically without any effect. On the tail, effect of AMPH did not differ 
      from that of MOR. All psychostimulants increased defecation in comparison with 
      MOR and in all groups the number of defecation boluses positively correlated with 
      analgesia of the hind limbs. We did not confirm that prenatal exposure to METH 
      makes adult rats more sensitive either to same drug or to other psychostimulants. 
      The different analgesic potencies of psychostimulants and MOR at different body 
      sites indicate the possible existence of a somatotopic organization of pain 
      inhibition, which is controlled by different mechanisms.
FAU - Yamamotova, A
AU  - Yamamotova A
AD  - Department of Normal, Pathological and Clinical Physiology, Third Faculty of 
      Medicine, Charles University in Prague, Prague, Czech Republic. 
      yamamoto@lf3.cuni.cz
FAU - Slamberova, R
AU  - Slamberova R
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Czech Republic
TA  - Physiol Res
JT  - Physiological research
JID - 9112413
RN  - 0 (Central Nervous System Stimulants)
RN  - 0 (Narcotics)
RN  - 44RAL3456C (Methamphetamine)
RN  - 76I7G6D29C (Morphine)
RN  - CK833KGX7E (Amphetamine)
RN  - I5Y540LHVR (Cocaine)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - Amphetamine/adverse effects/pharmacology
MH  - Animals
MH  - Behavior, Animal/drug effects
MH  - Central Nervous System Stimulants/adverse effects/*pharmacology
MH  - Cocaine/adverse effects/pharmacology
MH  - Female
MH  - Male
MH  - Methamphetamine/adverse effects/*pharmacology
MH  - Morphine/adverse effects/pharmacology
MH  - N-Methyl-3,4-methylenedioxyamphetamine/adverse effects/pharmacology
MH  - Narcotics/adverse effects/*pharmacology
MH  - Pregnancy
MH  - Prenatal Exposure Delayed Effects/metabolism/*physiopathology/*psychology
MH  - Rats
EDAT- 2012/11/21 06:00
MHDA- 2013/07/16 06:00
CRDT- 2012/11/08 06:00
PHST- 2012/11/08 06:00 [entrez]
PHST- 2012/11/21 06:00 [pubmed]
PHST- 2013/07/16 06:00 [medline]
AID - 932428 [pii]
AID - 10.33549/physiolres.932428 [doi]
PST - ppublish
SO  - Physiol Res. 2012;61(Suppl 2):S139-47. doi: 10.33549/physiolres.932428.