PMID- 23131825
OWN - NLM
STAT- MEDLINE
DCOM- 20130405
LR  - 20130128
IS  - 1097-6817 (Electronic)
IS  - 0194-5998 (Linking)
VI  - 148
IP  - 2
DP  - 2013 Feb
TI  - Oncologic and functional outcomes of partial laryngeal surgery for 
      intermediate-stage laryngeal cancer.
PG  - 235-42
LID - 10.1177/0194599812466367 [doi]
AB  - OBJECTIVE: To evaluate the oncologic and functional outcomes of partial laryngeal 
      surgery (PLS) using transoral laser microsurgery (TLM) and supracricoid 
      laryngectomy (SCL) in patients with intermediate-stage laryngeal squamous cell 
      carcinoma (LSCC). STUDY DESIGN: Historical cohort study. SETTING: Single tertiary 
      care center. SUBJECTS AND METHODS: Retrospective review of oncologic and 
      functional outcomes in intermediate-stage (T2-3/N0-1, stage II and III) LSCC 
      patients who underwent TLM or SCL from 1998 to 2010. RESULTS: Sixty patients were 
      included, of whom 28 (47%) underwent TLM and 32 (53%) underwent SCL. For the 
      entire cohort, 2- and 5-year probabilities were 86.2% (95% confidence interval 
      [CI], 73.0%-93.2%) and 72.9% (95% CI, 52.4%-85.6%), respectively, for overall 
      survival (OS) and 79.3% (95% CI, 65.6%-88.0%) and 62.4% (95% CI, 41.9%-77.4%), 
      respectively, for recurrence-free survival (RFS). There was no difference between 
      the TLM and SCL cohorts in OS (P = .542) or RFS (P = .483). More than 75% of 
      patients avoided adjuvant therapy. Communication Scale and Functional Outcome 
      Swallowing Scale scores at median follow-up of 33 months were 2 or better in 97% 
      and 91% of patients, respectively, reflecting functional voice and swallowing 
      postoperatively. Eighty-eight percent of patients retained a functional larynx. 
      CONCLUSION: PLS provides excellent oncologic and functional outcomes for 
      intermediate-stage LSCC and should be considered an alternative to chemoradiation 
      or total laryngectomy in selected patients.
FAU - Caicedo-Granados, Emiro
AU  - Caicedo-Granados E
AD  - Department of Otolaryngology, University of Minnesota School of Medicine, 
      Minneapolis, Minnesota, USA.
FAU - Beswick, Daniel M
AU  - Beswick DM
FAU - Christopoulos, Apostolos
AU  - Christopoulos A
FAU - Cunningham, Diana E
AU  - Cunningham DE
FAU - Razfar, Ali
AU  - Razfar A
FAU - Ohr, James P
AU  - Ohr JP
FAU - Heron, Dwight E
AU  - Heron DE
FAU - Ferris, Robert L
AU  - Ferris RL
LA  - eng
PT  - Journal Article
DEP - 20121106
PL  - England
TA  - Otolaryngol Head Neck Surg
JT  - Otolaryngology--head and neck surgery : official journal of American Academy of 
      Otolaryngology-Head and Neck Surgery
JID - 8508176
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Biopsy
MH  - Carcinoma, Squamous Cell/pathology/*surgery
MH  - Confidence Intervals
MH  - Female
MH  - Humans
MH  - Laryngeal Neoplasms/pathology/*surgery
MH  - Laryngectomy
MH  - Male
MH  - Middle Aged
MH  - Neck Dissection
MH  - Neoplasm Staging
MH  - Proportional Hazards Models
MH  - Recovery of Function
MH  - Retrospective Studies
MH  - Statistics, Nonparametric
MH  - Survival Rate
MH  - Treatment Outcome
EDAT- 2012/11/08 06:00
MHDA- 2013/04/06 06:00
CRDT- 2012/11/08 06:00
PHST- 2012/11/08 06:00 [entrez]
PHST- 2012/11/08 06:00 [pubmed]
PHST- 2013/04/06 06:00 [medline]
AID - 0194599812466367 [pii]
AID - 10.1177/0194599812466367 [doi]
PST - ppublish
SO  - Otolaryngol Head Neck Surg. 2013 Feb;148(2):235-42. doi: 
      10.1177/0194599812466367. Epub 2012 Nov 6.