PMID- 23131992
OWN - NLM
STAT- MEDLINE
DCOM- 20130708
LR  - 20221011
IS  - 1552-9924 (Electronic)
IS  - 0091-6765 (Print)
IS  - 0091-6765 (Linking)
VI  - 121
IP  - 2
DP  - 2013 Feb
TI  - Persistent organic pollutants and type 2 diabetes: a prospective analysis in the 
      nurses' health study and meta-analysis.
PG  - 153-61
LID - 10.1289/ehp.1205248 [doi]
AB  - BACKGROUND: Prospective data regarding persistent organic pollutants (POPs) and 
      risk of type 2 diabetes (T2D) are limited, and the results for individual POPs 
      are not entirely consistent across studies. OBJECTIVES: We prospectively examined 
      plasma POP concentrations in relation to incident T2D and summarized existing 
      evidence in a meta-analysis. METHODS: Plasma polychlorinated biphenyls (PCBs), 
      dichlorodiphenyltrichloroethane (DDT), dichlorodiphenyldichloroethylene (DDE), 
      and hexachlorobenzene (HCB) concentrations were measured in 1,095 women who were 
      free of diabetes at blood draw in 1989-1990 and participated in two case-control 
      studies in the Nurses' Health Study. We identified 48 incident T2D cases through 
      30 June 2008. We conducted a literature search in PubMed and EMBASE through 
      December 2011 to identify prospective studies on POPs in relation to diabetes. We 
      used a fixed-effects model to summarize results. RESULTS: After multivariable 
      adjustment, plasma HCB concentration was positively associated with incident T2D 
      [pooled odds ratio (OR) 3.59 (95% CI: 1.49, 8.64, ptrend = 0.003) comparing 
      extreme tertiles]. Other POPs were not significantly associated with diabetes. 
      After pooling our results with those of six published prospective studies that 
      included 842 diabetes cases in total, we found that HCB and total PCBs both were 
      associated with diabetes: the pooled ORs were 2.00 (95% CI: 1.13, 3.53; I2 = 
      21.4%, pheterogeneity = 0.28) and 1.70 (95% CI: 1.28, 2.27; I2 = 16.3%, 
      pheterogeneity = 0.30) for HCB and total PCBs, respectively. CONCLUSIONS: These 
      findings support an association between POP exposure and the risk of T2D.
FAU - Wu, Hongyu
AU  - Wu H
AD  - Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts 
      02115, USA.
FAU - Bertrand, Kimberly A
AU  - Bertrand KA
FAU - Choi, Anna L
AU  - Choi AL
FAU - Hu, Frank B
AU  - Hu FB
FAU - Laden, Francine
AU  - Laden F
FAU - Grandjean, Philippe
AU  - Grandjean P
FAU - Sun, Qi
AU  - Sun Q
LA  - eng
GR  - R01 DK058845/DK/NIDDK NIH HHS/United States
GR  - R01 CA098122/CA/NCI NIH HHS/United States
GR  - P01 CA087969/CA/NCI NIH HHS/United States
GR  - R00HL098459/HL/NHLBI NIH HHS/United States
GR  - R00 HL098459/HL/NHLBI NIH HHS/United States
GR  - CA49449/CA/NCI NIH HHS/United States
GR  - CA098122/CA/NCI NIH HHS/United States
GR  - DK46200/DK/NIDDK NIH HHS/United States
GR  - CA87969/CA/NCI NIH HHS/United States
GR  - DK58845/DK/NIDDK NIH HHS/United States
GR  - P30 DK046200/DK/NIDDK NIH HHS/United States
GR  - R25 CA098566/CA/NCI NIH HHS/United States
GR  - R01 CA049449/CA/NCI NIH HHS/United States
GR  - ES013692/ES/NIEHS NIH HHS/United States
GR  - T32 ES007155/ES/NIEHS NIH HHS/United States
GR  - R01 ES013692/ES/NIEHS NIH HHS/United States
GR  - U01 CA049449/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Meta-Analysis
PT  - Research Support, N.I.H., Extramural
PT  - Review
DEP - 20121105
PL  - United States
TA  - Environ Health Perspect
JT  - Environmental health perspectives
JID - 0330411
RN  - 0 (Environmental Pollutants)
RN  - 0 (Hydrocarbons, Chlorinated)
SB  - IM
MH  - Adult
MH  - Diabetes Mellitus, Type 2/*metabolism
MH  - Environmental Pollutants/*metabolism
MH  - Female
MH  - Humans
MH  - Hydrocarbons, Chlorinated/*metabolism
MH  - Middle Aged
MH  - *Nurses
MH  - Prospective Studies
PMC - PMC3569682
COIS- The authors declare they have no actual or potential competing financial 
      interests.
EDAT- 2012/11/08 06:00
MHDA- 2013/07/09 06:00
PMCR- 2013/02/01
CRDT- 2012/11/08 06:00
PHST- 2012/03/23 00:00 [received]
PHST- 2012/11/05 00:00 [accepted]
PHST- 2012/11/08 06:00 [entrez]
PHST- 2012/11/08 06:00 [pubmed]
PHST- 2013/07/09 06:00 [medline]
PHST- 2013/02/01 00:00 [pmc-release]
AID - ehp.1205248 [pii]
AID - 10.1289/ehp.1205248 [doi]
PST - ppublish
SO  - Environ Health Perspect. 2013 Feb;121(2):153-61. doi: 10.1289/ehp.1205248. Epub 
      2012 Nov 5.