PMID- 23132127
OWN - NLM
STAT- MEDLINE
DCOM- 20130809
LR  - 20220410
IS  - 1434-4726 (Electronic)
IS  - 0937-4477 (Linking)
VI  - 270
IP  - 3
DP  - 2013 Mar
TI  - Treatment for adult idiopathic and Wegener-associated subglottic stenosis.
PG  - 989-93
LID - 10.1007/s00405-012-2240-z [doi]
AB  - The aim of the study is to present the results of combination treatment for adult 
      non-traumatic subglottic stenosis (SGS). This is a retrospective chart review of 
      12 female patients (age range 32-76 years) with idiopathic SGS (eight patients) 
      and Wegener's granulomatosis. All patients had a hard and 11 a short (less than 1 
      cm) stenosis. Eleven patients were treated with endoscopic CO(2) laser, one with 
      Nd-YAG laser. Topical triamcinolone was applied to all. In 10 patients, topical 
      mitomycin C (MMC) was additionally applied. Symptom severity and airway 
      resistance (AR) were evaluated pre- and post-interventionally. Postoperatively, 
      oral steroids (and/or methotrexate) and proton pump inhibitors (PPI) were 
      prescribed. Follow-up period ranged between 7 and 115 months. All patients 
      reported a significant improvement in obstructive symptoms. Average AR 
      preoperatively was 1.004 kPa/(L/s) and postoperatively 0.526 kPa/(L/s). Three 
      patients underwent surgery once, 2 required a second surgery, 5 were operated 3 
      times, one 5 times, and one 7 times. The latter two patients had not received 
      local MMC treatment. Endoscopic laser surgery combined with local MMC and 
      triamcinolone application and postoperative oral steroid/methotrexate and PPI 
      therapy provides a treatment option that results in prolongation of the 
      symptom-free time intervals and avoidance of open surgery in patients with 
      idiopathic and Wegener-associated hard and short SGS.
FAU - Gouveris, Haralampos
AU  - Gouveris H
AD  - Department of Otolaryngology Head and Neck Surgery, University of Mainz Medical 
      Center, Langenbeckstr. 1, 55101, Mainz, Germany. hagouve@yahoo.de
FAU - Karaiskaki, Niki
AU  - Karaiskaki N
FAU - Koutsimpelas, Dimitrios
AU  - Koutsimpelas D
FAU - Chongolwatana, Cheerasook
AU  - Chongolwatana C
FAU - Mann, Wolf
AU  - Mann W
LA  - eng
PT  - Journal Article
DEP - 20121107
PL  - Germany
TA  - Eur Arch Otorhinolaryngol
JT  - European archives of oto-rhino-laryngology : official journal of the European 
      Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the 
      German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
JID - 9002937
RN  - 0 (Anti-Inflammatory Agents)
RN  - 0 (Nucleic Acid Synthesis Inhibitors)
RN  - 1ZK20VI6TY (Triamcinolone)
RN  - 50SG953SK6 (Mitomycin)
SB  - IM
MH  - Administration, Topical
MH  - Adult
MH  - Aged
MH  - Anti-Inflammatory Agents/*therapeutic use
MH  - Combined Modality Therapy
MH  - Female
MH  - Follow-Up Studies
MH  - Granulomatosis with Polyangiitis/*complications
MH  - Humans
MH  - Laryngoscopy
MH  - Laryngostenosis/etiology/*therapy
MH  - *Laser Therapy
MH  - Lasers, Gas/therapeutic use
MH  - Lasers, Solid-State/therapeutic use
MH  - Middle Aged
MH  - Mitomycin/*therapeutic use
MH  - Nucleic Acid Synthesis Inhibitors/*therapeutic use
MH  - Retrospective Studies
MH  - Triamcinolone/*therapeutic use
EDAT- 2012/11/08 06:00
MHDA- 2013/08/10 06:00
CRDT- 2012/11/08 06:00
PHST- 2012/08/23 00:00 [received]
PHST- 2012/10/18 00:00 [accepted]
PHST- 2012/11/08 06:00 [entrez]
PHST- 2012/11/08 06:00 [pubmed]
PHST- 2013/08/10 06:00 [medline]
AID - 10.1007/s00405-012-2240-z [doi]
PST - ppublish
SO  - Eur Arch Otorhinolaryngol. 2013 Mar;270(3):989-93. doi: 
      10.1007/s00405-012-2240-z. Epub 2012 Nov 7.