PMID- 23133742
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121108
LR  - 20211021
IS  - 2090-0392 (Electronic)
IS  - 2090-0384 (Print)
VI  - 2012
DP  - 2012
TI  - Investigation of homocysteine-pathway-related variants in essential hypertension.
PG  - 190923
LID - 10.1155/2012/190923 [doi]
LID - 190923
AB  - Hyperhomocysteinemia (hHcy) has been associated with an increased risk of 
      cardiovascular disease and stroke. Essential hypertension (EH), a polygenic 
      condition, has also been associated with increased risk of cardiovascular related 
      disorders. To investigate the role of the homocysteine (Hcy) metabolism pathway 
      in hypertension we conducted a case-control association study of Hcy pathway gene 
      variants in a cohort of Caucasian hypertensives and age- and sex-matched 
      normotensives. We genotyped two polymorphisms in the methylenetetrahydrofolate 
      reductase gene (MTHFR C677T and MTHFR A1298C), one polymorphism in the methionine 
      synthase reductase gene (MTRR A66G), and one polymorphism in the 
      methylenetetrahydrofolate dehydrogenase 1 gene (MTHFD1 G1958A) and assessed their 
      association with hypertension using chi-square analysis. We also performed a 
      multifactor dimensionality reduction (MDR) analysis to investigate any potential 
      epistatic interactions among the four polymorphisms and EH. None of the four 
      polymorphisms was significantly associated with EH and although we found a 
      moderate synergistic interaction between MTHFR A1298C and MTRR A66G, the 
      association of the interaction model with EH was not statistically significant (P 
      = 0.2367). Our findings therefore suggest no individual or interactive 
      association between four prominent Hcy pathway markers and EH.
FAU - Fowdar, Javed Y
AU  - Fowdar JY
AD  - Genomics Research Centre, Griffith Health Institute, Gold Coast Campus, Griffith 
      University, Southport, QLD 4222, Australia.
FAU - Lason, Marta V
AU  - Lason MV
FAU - Szvetko, Attila L
AU  - Szvetko AL
FAU - Lea, Rodney A
AU  - Lea RA
FAU - Griffiths, Lyn R
AU  - Griffiths LR
LA  - eng
PT  - Journal Article
DEP - 20121023
PL  - United States
TA  - Int J Hypertens
JT  - International journal of hypertension
JID - 101538881
PMC - PMC3485977
EDAT- 2012/11/08 06:00
MHDA- 2012/11/08 06:01
PMCR- 2012/10/23
CRDT- 2012/11/08 06:00
PHST- 2012/03/21 00:00 [received]
PHST- 2012/09/05 00:00 [revised]
PHST- 2012/09/18 00:00 [accepted]
PHST- 2012/11/08 06:00 [entrez]
PHST- 2012/11/08 06:00 [pubmed]
PHST- 2012/11/08 06:01 [medline]
PHST- 2012/10/23 00:00 [pmc-release]
AID - 10.1155/2012/190923 [doi]
PST - ppublish
SO  - Int J Hypertens. 2012;2012:190923. doi: 10.1155/2012/190923. Epub 2012 Oct 23.