PMID- 23135204
OWN - NLM
STAT- MEDLINE
DCOM- 20140401
LR  - 20130828
IS  - 1791-3004 (Electronic)
IS  - 1791-2997 (Linking)
VI  - 7
IP  - 1
DP  - 2013 Jan
TI  - Effects of exercise therapy on knee joint function and synovial fluid cytokine 
      levels in patients with knee osteoarthritis.
PG  - 183-6
LID - 10.3892/mmr.2012.1168 [doi]
AB  - The aims of this study were to observe the effect of exercise therapy on the 
      function of the knee joint and the levels of cytokines and cytokine-related 
      genes, specifically tumor necrosis factor-alpha (TNF-alpha), high sensitivity C-reactive 
      protein (hs-CRP) and matrix metalloproteinase-3 (MMP-3), in the synovial joints 
      of patients with knee osteoarthritis (KOA) and to explore its mechanism of 
      action. A total of 100 KOA patients were divided into a treatment group (n=50) 
      and a control group (n=50) according to the order of admission. The patients in 
      the treatment group were treated with diclofenac sodium combined with exercise 
      therapy and the patients in the control group were treated with diclofenac sodium 
      only. The function of the knee joint and the therapeutic efficacy was evaluated 
      and the TNF-alpha, hs-CRP and MMP-3 levels in the synovial fluid were measured 
      following 4 weeks of treatment. The results revealed that the knee joint index 
      score and the TNF-alpha, hs-CRP and MMP-3 levels in the synovial fluid decreased 
      significantly in the KOA patients of the two groups following treatment (P<0.05). 
      Compared with the control group, the knee joint index score and the TNF-alpha, hs-CRP 
      and MMP-3 levels in the synovial joints were lower and the therapeutic efficacy 
      was increased in the patients of the treatment group (P<0.05). In brief, exercise 
      therapy may decrease cytokine and cytokine-related gene levels in the synovial 
      fluid and inhibit inflammatory factor-mediated cartilage degradation in KOA 
      patients, thus, effectively improving the clinical symptoms of KOA.
FAU - Zhang, Shao-Lan
AU  - Zhang SL
AD  - Department of Medical Technology, Yancheng Health Vocational and Technical 
      College, Yancheng 224006, PR China. shaolan2004@126.com
FAU - Liu, Hong-Qi
AU  - Liu HQ
FAU - Xu, Xiao-Zu
AU  - Xu XZ
FAU - Zhi, Juan
AU  - Zhi J
FAU - Geng, Jiao-Jiao
AU  - Geng JJ
FAU - Chen, Jin
AU  - Chen J
LA  - eng
PT  - Journal Article
DEP - 20121107
PL  - Greece
TA  - Mol Med Rep
JT  - Molecular medicine reports
JID - 101475259
RN  - 0 (Cytokines)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 9007-41-4 (C-Reactive Protein)
RN  - EC 3.4.24.17 (Matrix Metalloproteinase 3)
SB  - IM
MH  - Adult
MH  - C-Reactive Protein/metabolism
MH  - Cytokines/*metabolism
MH  - *Exercise Therapy
MH  - Female
MH  - Humans
MH  - Male
MH  - Matrix Metalloproteinase 3/metabolism
MH  - Middle Aged
MH  - Osteoarthritis, Knee/*metabolism/*physiopathology/therapy
MH  - Synovial Fluid/*metabolism
MH  - Treatment Outcome
MH  - Tumor Necrosis Factor-alpha/metabolism
EDAT- 2012/11/09 06:00
MHDA- 2014/04/02 06:00
CRDT- 2012/11/09 06:00
PHST- 2012/04/24 00:00 [received]
PHST- 2012/09/10 00:00 [accepted]
PHST- 2012/11/09 06:00 [entrez]
PHST- 2012/11/09 06:00 [pubmed]
PHST- 2014/04/02 06:00 [medline]
AID - 10.3892/mmr.2012.1168 [doi]
PST - ppublish
SO  - Mol Med Rep. 2013 Jan;7(1):183-6. doi: 10.3892/mmr.2012.1168. Epub 2012 Nov 7.