PMID- 23135319
OWN - NLM
STAT- MEDLINE
DCOM- 20130425
LR  - 20211021
IS  - 1720-8386 (Electronic)
IS  - 0391-4097 (Linking)
VI  - 35
IP  - 9
DP  - 2012 Oct
TI  - Asymmetric dimethylarginine and carotid atherosclerosis in Type 2 diabetes 
      mellitus.
PG  - 824-7
AB  - BACKGROUND: Circulating asymmetric dimethylarginine (ADMA) concentration is 
      elevated in patients with Type 2 diabetes mellitus (T2DM). AIM: To assess the 
      relationship between plasma ADMA concentration and carotid atherosclerosis in 
      patients with T2DM. SUBJECTS AND METHODS: A total of 72 newly diagnosed and 
      untreated T2DM individuals and 72 healthy controls were studied. Carotid 
      atherosclerosis was determined by ultrasonographically evaluated intima- media 
      thickness (IMT) and plaque score. Plasma concentration of ADMA was measured by 
      high-performance liquid chromatography. RESULTS: Plasma ADMA, mean IMT, and 
      plaque score were higher in diabetic patients compared with controls. Univariate 
      and multivariate analyses demonstrated an independent association between ADMA 
      and mean IMT in diabetic patients. On a multiple logistic regression analysis, 
      ADMA was the sole predictor of carotid plaque formation (plaque score >/=1.1) (odds 
      ratio 2.43, 95% confidence interval 1.19 to 4.94, p<0.05). CONCLUSION: Our 
      results suggest that increased levels of ADMA might be involved in the 
      development of carotid atherosclerosis in T2DM.
FAU - Xia, W
AU  - Xia W
AD  - Department of Cardiology, Qingdao Municipal Hospital, the Affiliated Hospital of 
      Ocean University of China, Shandong, China.
FAU - Shao, Y
AU  - Shao Y
FAU - Wang, Y
AU  - Wang Y
FAU - Wang, X
AU  - Wang X
FAU - Chi, Y
AU  - Chi Y
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - Italy
TA  - J Endocrinol Invest
JT  - Journal of endocrinological investigation
JID - 7806594
RN  - 63CV1GEK3Y (N,N-dimethylarginine)
RN  - 94ZLA3W45F (Arginine)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Arginine/*analogs & derivatives/metabolism
MH  - Carotid Artery Diseases/*etiology/metabolism
MH  - Case-Control Studies
MH  - Diabetes Complications/*etiology/metabolism
MH  - Diabetes Mellitus, Type 2/*physiopathology
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Prognosis
EDAT- 2012/11/09 06:00
MHDA- 2013/04/26 06:00
CRDT- 2012/11/09 06:00
PHST- 2012/11/09 06:00 [entrez]
PHST- 2012/11/09 06:00 [pubmed]
PHST- 2013/04/26 06:00 [medline]
AID - 8692 [pii]
AID - 10.1007/BF03347101 [doi]
PST - ppublish
SO  - J Endocrinol Invest. 2012 Oct;35(9):824-7. doi: 10.1007/BF03347101.