PMID- 23135705
OWN - NLM
STAT- MEDLINE
DCOM- 20140320
LR  - 20221207
IS  - 1590-3478 (Electronic)
IS  - 1590-1874 (Linking)
VI  - 34
IP  - 8
DP  - 2013 Aug
TI  - Association of monocyte chemoattractant protein-1 -2518A>G polymorphism with 
      occurrence, severity, and outcome in ischemic stroke.
PG  - 1315-20
LID - 10.1007/s10072-012-1235-2 [doi]
AB  - Monocyte chemoattractant protein-1 (MCP-1) is implicated in promoting 
      atherosclerotic diseases, including stroke. Therefore, several studies have 
      investigated the association between variants of the MCP-1 gene and risk of 
      atherosclerotic diseases. We sought to determine the occurrence of MCP-1 -2518A>G 
      polymorphism in patients with ischemic stroke (IS), and studied its association 
      with the severity of disease and functional outcome after an acute IS. One 
      hundred and forty-five consecutive patients with first ever IS and 145 age- and 
      sex-matched control subjects were recruited. Stroke severity and functional 
      outcome were assessed on admission and at one month post-stroke, respectively. 
      Genotyping for the MCP-1 -2518A>G polymorphism was performed by a polymerase 
      chain reaction-restriction fragment length polymorphism (PCR-RFLP). No 
      significant difference in the frequency of MCP-1 -2518A>G genotypes between IS 
      patients and controls was found, with OR = 0.69 (95 % CI 0.46-1.04, P = 0.08). 
      Moreover, carriage of the G allele was not associated with stroke severity 
      (Scandinavian stroke scale score 33.1 vs. 32.5, respectively, P = 0.71), or poor 
      outcome at 1 month post-stroke (63.9 vs. 59.7 %, respectively, P = 0.61). In 
      conclusion, we were unable to demonstrate a significant association of the MCP-1 
      -2518A>G gene polymorphism with IS occurrence, severity or functional outcome in 
      a Caucasian population. However, larger studies are necessary to fully elucidate 
      the role of this polymorphism in IS.
FAU - Giannakopoulou, Efstathia
AU  - Giannakopoulou E
AD  - Laboratory of Pharmacology, Medical School, Democritus University of Thrace, 
      Dragana Campus, 68100, Alexandroupolis, Greece.
FAU - Ragia, Georgia
AU  - Ragia G
FAU - Marousi, Stella
AU  - Marousi S
FAU - Ellul, John
AU  - Ellul J
FAU - Manolopoulos, Vangelis G
AU  - Manolopoulos VG
FAU - Tavridou, Anna
AU  - Tavridou A
LA  - eng
PT  - Journal Article
DEP - 20121108
PL  - Italy
TA  - Neurol Sci
JT  - Neurological sciences : official journal of the Italian Neurological Society and 
      of the Italian Society of Clinical Neurophysiology
JID - 100959175
RN  - 0 (Chemokine CCL2)
SB  - IM
MH  - Aged
MH  - Brain Ischemia/diagnosis/epidemiology/*genetics
MH  - Chemokine CCL2/*genetics
MH  - Female
MH  - Greece
MH  - Humans
MH  - Male
MH  - *Polymorphism, Genetic
MH  - Stroke/diagnosis/epidemiology/*genetics
MH  - White People
EDAT- 2012/11/09 06:00
MHDA- 2014/03/22 06:00
CRDT- 2012/11/09 06:00
PHST- 2012/05/25 00:00 [received]
PHST- 2012/10/25 00:00 [accepted]
PHST- 2012/11/09 06:00 [entrez]
PHST- 2012/11/09 06:00 [pubmed]
PHST- 2014/03/22 06:00 [medline]
AID - 10.1007/s10072-012-1235-2 [doi]
PST - ppublish
SO  - Neurol Sci. 2013 Aug;34(8):1315-20. doi: 10.1007/s10072-012-1235-2. Epub 2012 Nov 
      8.