PMID- 23136965
OWN - NLM
STAT- MEDLINE
DCOM- 20140924
LR  - 20220331
IS  - 1525-1403 (Electronic)
IS  - 1094-7159 (Linking)
VI  - 16
IP  - 6
DP  - 2013 Nov-Dec
TI  - Cerebrospinal fluid levels of vascular endothelial growth factor correlate with 
      reported pain and are reduced by spinal cord stimulation in patients with failed 
      back surgery syndrome.
PG  - 519-22; discussion 522
LID - 10.1111/j.1525-1403.2012.00527.x [doi]
AB  - OBJECTIVES: Spinal cord stimulation (SCS) is an efficacious therapy for chronic 
      neuropathic pain whose precise mechanism of action is unclear. Mediators produced 
      by glial and immune cells are now believed to modulate neuronal transmission and 
      promote chronic neuropathic pain. We postulated a relationship between 
      cerebrospinal fluid (CSF) concentrations of neuroimmune mediators and SCS. 
      MATERIALS AND METHODS: We measured CSF concentrations of the chemokine, monocyte 
      chemotactic protein-1 (MCP-1), and the growth factors, brain-derived neurotrophic 
      factor (BDNF), and vascular endothelial growth factor (VEGF) and tested for 
      relationships with stimulation parameters and clinical response in nine patients 
      with failed back surgery syndrome (FBSS). RESULTS: Patients with FBSS had higher 
      CSF concentrations of BDNF (p = 0.01) and MCP-1 (p = 0.0001) than matched 
      controls. CSF concentrations of BDNF and VEGF correlated with reported pain (p = 
      0.04). Five minutes of SCS resulted in a reduction in median VEGF concentrations 
      (p = 0.01). CONCLUSIONS: Patients with FBSS have altered CSF levels of BDNF and 
      MCP-1. CSF VEGF correlates with pain and is reduced by SCS. This may offer novel 
      insights into both the mechanism of action of SCS in FBSS and the variation in 
      clinical response that may be encountered.
CI  - (c) 2012 International Neuromodulation Society.
FAU - McCarthy, Kevin F
AU  - McCarthy KF
AD  - Department of Pain Medicine, St James's Hospital, Dublin, Ireland.
FAU - Connor, Thomas J
AU  - Connor TJ
FAU - McCrory, Connail
AU  - McCrory C
LA  - eng
PT  - Journal Article
DEP - 20121108
PL  - United States
TA  - Neuromodulation
JT  - Neuromodulation : journal of the International Neuromodulation Society
JID - 9804159
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (CCL2 protein, human)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Chemokines)
RN  - 0 (Vascular Endothelial Growth Factor A)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Brain-Derived Neurotrophic Factor/cerebrospinal fluid
MH  - Chemokine CCL2/cerebrospinal fluid
MH  - Chemokines/cerebrospinal fluid
MH  - Failed Back Surgery Syndrome/*cerebrospinal fluid/complications/*therapy
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Neuralgia/*cerebrospinal fluid/etiology/*therapy
MH  - Pain Measurement
MH  - *Spinal Cord Stimulation
MH  - Treatment Outcome
MH  - Vascular Endothelial Growth Factor A/*cerebrospinal fluid
OTO - NOTNLM
OT  - basic science
OT  - failed back surgery syndrome
OT  - mechanisms of action
OT  - nonrandomized study
OT  - prospective
OT  - spinal cord stimulation
EDAT- 2012/11/10 06:00
MHDA- 2014/09/25 06:00
CRDT- 2012/11/10 06:00
PHST- 2012/05/20 00:00 [received]
PHST- 2012/08/15 00:00 [revised]
PHST- 2012/09/13 00:00 [accepted]
PHST- 2012/11/10 06:00 [entrez]
PHST- 2012/11/10 06:00 [pubmed]
PHST- 2014/09/25 06:00 [medline]
AID - S1094-7159(14)60006-4 [pii]
AID - 10.1111/j.1525-1403.2012.00527.x [doi]
PST - ppublish
SO  - Neuromodulation. 2013 Nov-Dec;16(6):519-22; discussion 522. doi: 
      10.1111/j.1525-1403.2012.00527.x. Epub 2012 Nov 8.