PMID- 23137677
OWN - NLM
STAT- MEDLINE
DCOM- 20130626
LR  - 20170112
IS  - 0392-856X (Print)
IS  - 0392-856X (Linking)
VI  - 31
IP  - 2
DP  - 2013 Mar-Apr
TI  - Leptin, adiponectin, resistin, visfatin serum levels and idiopathic recurrent 
      pericarditis: biomarkers of disease activity? A preliminary report.
PG  - 207-12
AB  - OBJECTIVES: Idiopathic recurrent acute pericarditis (IRAP) represents the most 
      troublesome complication of acute pericarditis and is an autoimmune process. 
      White adipose tissue produces more than 50 adipokines that participate in 
      inflammation and autoimmunity. This study investigated whether serum leptin, 
      resistin, visfatin and adiponectin are increased in IRAP versus healthy controls 
      and if their levels correlate with parameters of disease activity. METHODS: Serum 
      leptin, resistin, visfatin and adiponectin levels were assayed by enzyme-linked 
      immunosorbent assay in 14 IRAP patients during recurrences (group 1), in 23 IRAP 
      patients during symptom-free intervals (group 2) and in 18 healthy controls 
      (group 3). Assessment parameters included demographic characteristics of patients 
      and controls, clinical characteristics of patients and markers of inflammation. 
      Comparisons between groups as well as reciprocal comparisons were evaluated. 
      RESULTS: Group 1 showed serum leptin (p<0.008), visfatin (p<0.002), and 
      adiponectin (p<0.04) significantly higher than group 2 and control group, whereas 
      resistin serum levels did not significantly differ (p=0.69). Among IRAP patients, 
      serum leptin significantly correlated with serum amyloid A (SAA) levels (rs=0.43, 
      r2= 0.27, p<0.02). Other than this correlation, none of the considered adipokines 
      significantly correlated with the other considered variables in univariate 
      analysis. CONCLUSIONS: Leptin, adiponectin and visfatin are increased in IRAP 
      patients versus healthy controls. Our data suggest that these adipokines might be 
      involved in IRAP pathogenesis and that a possible increased cardiovascular risk 
      in these patients, through an early onset atherosclerosis, should be kept in 
      mind. SAA might be a link between IRAP and increased cardiovascular diseases.
FAU - Cantarini, Luca
AU  - Cantarini L
AD  - University of Siena, Siena, Italy. cantariniluca@hotmail.com
FAU - Brucato, Antonio
AU  - Brucato A
FAU - Simonini, Gabriele
AU  - Simonini G
FAU - Imazio, Massimo
AU  - Imazio M
FAU - Cumetti, Davide
AU  - Cumetti D
FAU - Cimaz, Rolando
AU  - Cimaz R
FAU - Bacarelli, Maria Romana
AU  - Bacarelli MR
FAU - Muscari, Isabella
AU  - Muscari I
FAU - Vitale, Antonio
AU  - Vitale A
FAU - Lucherini, Orso Maria
AU  - Lucherini OM
FAU - Galeazzi, Mauro
AU  - Galeazzi M
FAU - Fioravanti, Antonella
AU  - Fioravanti A
LA  - eng
PT  - Journal Article
DEP - 20121108
PL  - Italy
TA  - Clin Exp Rheumatol
JT  - Clinical and experimental rheumatology
JID - 8308521
RN  - 0 (ADIPOQ protein, human)
RN  - 0 (Adiponectin)
RN  - 0 (Biomarkers)
RN  - 0 (Cytokines)
RN  - 0 (Leptin)
RN  - 0 (RETN protein, human)
RN  - 0 (Resistin)
RN  - 0 (Serum Amyloid A Protein)
RN  - EC 2.4.2.12 (Nicotinamide Phosphoribosyltransferase)
RN  - EC 2.4.2.12 (nicotinamide phosphoribosyltransferase, human)
SB  - IM
MH  - Adiponectin/*blood
MH  - Adult
MH  - Analysis of Variance
MH  - Biomarkers/blood
MH  - Case-Control Studies
MH  - Cross-Sectional Studies
MH  - Cytokines/*blood
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Humans
MH  - Leptin/*blood
MH  - Male
MH  - Middle Aged
MH  - Nicotinamide Phosphoribosyltransferase/*blood
MH  - Pericarditis/*blood/diagnosis
MH  - Predictive Value of Tests
MH  - Prognosis
MH  - Recurrence
MH  - Regression Analysis
MH  - Resistin/*blood
MH  - Serum Amyloid A Protein/analysis
MH  - Severity of Illness Index
MH  - Up-Regulation
EDAT- 2012/11/10 06:00
MHDA- 2013/06/28 06:00
CRDT- 2012/11/10 06:00
PHST- 2012/04/10 00:00 [received]
PHST- 2012/06/13 00:00 [accepted]
PHST- 2012/11/10 06:00 [entrez]
PHST- 2012/11/10 06:00 [pubmed]
PHST- 2013/06/28 06:00 [medline]
AID - 6038 [pii]
PST - ppublish
SO  - Clin Exp Rheumatol. 2013 Mar-Apr;31(2):207-12. Epub 2012 Nov 8.