PMID- 23138006
OWN - NLM
STAT- MEDLINE
DCOM- 20140519
LR  - 20160803
IS  - 1708-8267 (Electronic)
IS  - 1081-5589 (Linking)
VI  - 60
IP  - 8
DP  - 2012 Dec
TI  - High-protein diets alters body composition and improves insulin resistance in a 
      rat model of low birth weight.
PG  - 1174-9
LID - 10.2310/JIM.0b013e3182746ce8 [doi]
AB  - OBJECTIVE: We aimed to investigate the effects of early high-protein 
      supplementation on low birth weight (LBW)-associated adult metabolic 
      disturbances. MATERIALS AND METHODS: This study involved 32 LBW rat pups that 
      were fed a normal protein (20% of energy intake) diet or high-protein (30% of 
      energy intake) diet on their first 4 weeks of life. Sixteen rat pups with normal 
      birth weight (NBW) fed the normal-protein diet were included as control. 
      Biochemical measurements were performed at 4 and 12 weeks of age. RESULTS: Low 
      birth weight offspring showed significantly (P < 0.05) increased fat mass 
      percentage and adipocyte size and decreased lean mass percentage and muscle fiber 
      size relative to NBW offspring. These LBW-related changes in body composition 
      were corrected by high-protein diet intervention. At 12 weeks of age, the fasting 
      insulin level (7.14 +/- 0.83 vs 9.27 +/- 0.67 mU/L) and homeostasis model of insulin 
      resistance (1.71 +/- 0.35 vs 2.30 +/- 0.44) were significantly lower in high 
      protein-fed LBW offspring than in normal protein-fed LBW offspring. Low birth 
      weight rat pups showed a significant (P < 0.05) reduction in serum adiponectin 
      concentrations, glucose transporter 4 mRNA abundance, and phosphorylation levels 
      of AMP-activated protein kinase (AMPK) and mammalian target of rapamycin (mTOR) 
      relative to NBW controls. These LBW-associated alterations in gene expression 
      were reversed by early high-protein treatment. CONCLUSIONS: Early postnatal 
      high-protein intake alters the body composition and improves insulin resistance 
      in adults with LBW, which is associated with activation of the AMPK and mTOR 
      pathways.
FAU - Yu, Mu-xue
AU  - Yu MX
AD  - Department of Pediatrics, First Affiliated Hospital of Sun Yat-Sen University, 
      Guangzhou, China.
FAU - Shen, Zhen-yu
AU  - Shen ZY
FAU - Qiu, Xiao-shan
AU  - Qiu XS
FAU - Mo, Qing-ping
AU  - Mo QP
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Investig Med
JT  - Journal of investigative medicine : the official publication of the American 
      Federation for Clinical Research
JID - 9501229
RN  - 0 (Dietary Proteins)
SB  - IM
MH  - Animals
MH  - Animals, Newborn
MH  - Birth Weight/*physiology
MH  - Body Composition/*physiology
MH  - Dietary Proteins/administration & dosage/*metabolism
MH  - Female
MH  - Insulin Resistance/*physiology
MH  - *Models, Animal
MH  - Pregnancy
MH  - Random Allocation
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Thinness/diet therapy/*metabolism
EDAT- 2012/11/10 06:00
MHDA- 2014/05/20 06:00
CRDT- 2012/11/10 06:00
PHST- 2012/11/10 06:00 [entrez]
PHST- 2012/11/10 06:00 [pubmed]
PHST- 2014/05/20 06:00 [medline]
AID - 10.2310/JIM.0b013e3182746ce8 [doi]
PST - ppublish
SO  - J Investig Med. 2012 Dec;60(8):1174-9. doi: 10.2310/JIM.0b013e3182746ce8.