PMID- 23138554
OWN - NLM
STAT- MEDLINE
DCOM- 20130509
LR  - 20211021
IS  - 1435-1250 (Electronic)
IS  - 0340-1855 (Linking)
VI  - 71
IP  - 9
DP  - 2012 Nov
TI  - [Update Churg-Strauss syndrome].
PG  - 765-70
LID - 10.1007/s00393-012-0985-9 [doi]
AB  - The Churg-Strauss syndrome (CSS) is the rarest subtype of the so-called 
      anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitides (AAV) and has 
      the lowest frequency of ANCA-positivity (around 30%). In addition to asthma and 
      blood eosinophilia, CSS is characterized by end-organ damage, which can be caused 
      by either vasculitis and/or tissue infiltration of eosinophilic granulocytes. The 
      CSS shares many etiological and clinical features of other hypereosinophilic 
      syndromes. Recently, a distinct genetic background could be demonstrated for both 
      the ANCA-positive and ANCA-negative subtypes of CSS as compared to the other two 
      forms of AAV. Among other cytokines, interleukin-5 (IL-5) could be identified as 
      a key mediator of eosinophilia. Therefore, recent clinical trials in CSS aimed to 
      target IL-5. Outside of clinical trials, treatment of CSS is adapted to disease 
      stage and activity, as recommended for other types of AAV.
FAU - Moosig, F
AU  - Moosig F
AD  - Klinik fur Rheumatologie und Immunologie, Klinikum Bad Bramstedt GmbH, 
      Universitatsklinikum Schleswig Holstein, Oskar-Alexander-Str. 26, 24576, Bad 
      Bramstedt, Deutschland. F.Moosig@klinikumbb.de
FAU - Hellmich, B
AU  - Hellmich B
LA  - ger
PT  - English Abstract
PT  - Journal Article
TT  - Update Churg-Strauss-Syndrom.
PL  - Germany
TA  - Z Rheumatol
JT  - Zeitschrift fur Rheumatologie
JID - 0414162
RN  - 0 (Immunosuppressive Agents)
SB  - IM
MH  - Churg-Strauss Syndrome/complications/*diagnosis/*drug therapy
MH  - Eosinophilia/*diagnosis/etiology/*prevention & control
MH  - Humans
MH  - Immunosuppressive Agents/*therapeutic use
MH  - Multiple Organ Failure/*diagnosis/etiology/*prevention & control
EDAT- 2012/11/10 06:00
MHDA- 2013/05/10 06:00
CRDT- 2012/11/10 06:00
PHST- 2012/11/10 06:00 [entrez]
PHST- 2012/11/10 06:00 [pubmed]
PHST- 2013/05/10 06:00 [medline]
AID - 10.1007/s00393-012-0985-9 [doi]
PST - ppublish
SO  - Z Rheumatol. 2012 Nov;71(9):765-70. doi: 10.1007/s00393-012-0985-9.