PMID- 23138706
OWN - NLM
STAT- MEDLINE
DCOM- 20130821
LR  - 20220408
IS  - 1724-6040 (Electronic)
IS  - 0391-3988 (Linking)
VI  - 35
IP  - 10
DP  - 2012 Oct
TI  - Epidemiology and new developments in the diagnosis of prosthetic joint infection.
PG  - 923-34
LID - 10.5301/ijao.5000168 [doi]
AB  - Although prosthetic joint infection (PJI) is a rare event after arthroplasty, it 
      represents a significant complication that is associated with high morbidity, 
      need for complex treatment, and substantial healthcare costs. An accurate and 
      rapid diagnosis of PJI is crucial for treatment success. Current diagnostic 
      methods in PJI are insufficient with 10-30% false-negative cultures. 
      Consequently, there is a need for research and development into new methods aimed 
      at improving diagnostic accuracy and speed of detection. In this article, we 
      review available conventional diagnostic methods for the diagnosis of PJI 
      (laboratory markers, histopathology, synovial fluid and periprosthetic tissue 
      cultures), new diagnostic methods (sonication of implants, specific and multiplex 
      PCR, mass spectrometry) and innovative techniques under development (new 
      laboratory markers, microcalorimetry, electrical method, reverse transcription 
      [RT]-PCR, fluorescence in situ hybridization [FISH], biofilm microscopy, 
      microarray identification, and serological tests). The results of highly 
      sensitive diagnostic techniques with unknown specificity should be interpreted 
      with caution. The organism identified by a new method may represent a real 
      pathogen that was unrecognized by conventional diagnostic methods or 
      contamination during specimen sampling, transportation, or processing. For 
      accurate interpretation, additional studies are needed, which would evaluate the 
      long-term outcome (usually >2 years) with or without antimicrobial treatment. It 
      is expected that new rapid, accurate, and fully automatic diagnostic tests will 
      be developed soon.
FAU - Corvec, Stephane
AU  - Corvec S
AD  - Service de Bacteriologie-Hygiene, CHU de Nantes, Nantes, France.
FAU - Portillo, Maria E
AU  - Portillo ME
FAU - Pasticci, Bruna Maria
AU  - Pasticci BM
FAU - Borens, Olivier
AU  - Borens O
FAU - Trampuz, Andrej
AU  - Trampuz A
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Int J Artif Organs
JT  - The International journal of artificial organs
JID - 7802649
SB  - IM
MH  - Arthroplasty, Replacement/*adverse effects/instrumentation
MH  - *Bacteriological Techniques
MH  - False Negative Reactions
MH  - Humans
MH  - Joint Prosthesis/*adverse effects/microbiology
MH  - Predictive Value of Tests
MH  - Prognosis
MH  - Prosthesis-Related Infections/*diagnosis/*epidemiology/microbiology
EDAT- 2012/11/10 06:00
MHDA- 2013/08/22 06:00
CRDT- 2012/11/10 06:00
PHST- 2012/07/15 00:00 [accepted]
PHST- 2012/11/10 06:00 [entrez]
PHST- 2012/11/10 06:00 [pubmed]
PHST- 2013/08/22 06:00 [medline]
AID - A01844D7-C32A-44F8-9EE2-C12ADE2E8012 [pii]
AID - 10.5301/ijao.5000168 [doi]
PST - ppublish
SO  - Int J Artif Organs. 2012 Oct;35(10):923-34. doi: 10.5301/ijao.5000168.