PMID- 23139375
OWN - NLM
STAT- MEDLINE
DCOM- 20130918
LR  - 20220321
IS  - 1935-5548 (Electronic)
IS  - 0149-5992 (Print)
IS  - 0149-5992 (Linking)
VI  - 36
IP  - 4
DP  - 2013 Apr
TI  - Association between BMI measured within a year after diagnosis of type 2 diabetes 
      and mortality.
PG  - 887-93
LID - 10.2337/dc12-0944 [doi]
AB  - OBJECTIVE: To describe the association of BMI with mortality in patients 
      diagnosed with type 2 diabetes. RESEARCH DESIGN AND METHODS: Using records of 
      106,640 patients in Scotland, we investigated the association between BMI 
      recorded around the diagnosis of type 2 diabetes mellitus (T2DM) and mortality 
      using Cox proportional hazards regression adjusted for age and smoking status, 
      with BMI 25 to <30 kg/m(2) as a referent group. Deaths within 2 years of BMI 
      determination were excluded. Mean follow-up to death or the end of 2007 was 4.7 
      years. RESULTS: A total of 9,631 deaths occurred between 2001 and 2007. Compared 
      with the reference group, mortality risk was higher in patients with BMI 20 to 
      <25 kg/m(2) (hazard ratio 1.22 [95% CI 1.13-1.32] in men, 1.32 [1.22-1.44] in 
      women) and patients with BMI >/=35 kg/m(2) (for example, 1.70 [1.24-2.34] in men 
      and 1.81 [1.46-2.24] in women for BMI 45 to <50 kg/m(2)). Vascular mortality was 
      higher for each 5-kg/m(2) increase in BMI >30 kg/m(2) by 24% (15-35%) in men and 
      23% (14-32%) in women, but was lower below this threshold. The results were 
      similar after further adjustment for HbA1c, year of diagnosis, lipids, blood 
      pressure, and socioeconomic status. CONCLUSIONS: Patients categorized as normal 
      weight or obese with T2DM within a year of diagnosis of T2DM exhibit variably 
      higher mortality outcomes compared with the overweight group, confirming a 
      U-shaped association of BMI with mortality. Whether weight loss interventions 
      reduce mortality in all T2DM patients requires study.
FAU - Logue, Jennifer
AU  - Logue J
AD  - Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, 
      United Kingdom. jennifer.logue@glasgow.ac.uk
FAU - Walker, Jeremy J
AU  - Walker JJ
FAU - Leese, Graham
AU  - Leese G
FAU - Lindsay, Robert
AU  - Lindsay R
FAU - McKnight, John
AU  - McKnight J
FAU - Morris, Andrew
AU  - Morris A
FAU - Philip, Sam
AU  - Philip S
FAU - Wild, Sarah
AU  - Wild S
FAU - Sattar, Naveed
AU  - Sattar N
CN  - Scottish Diabetes Research Network Epidemiology Group
LA  - eng
GR  - 090532/WT_/Wellcome Trust/United Kingdom
GR  - WT086113/WT_/Wellcome Trust/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121108
PL  - United States
TA  - Diabetes Care
JT  - Diabetes care
JID - 7805975
SB  - IM
MH  - *Body Mass Index
MH  - Diabetes Mellitus, Type 2/*diagnosis/*mortality
MH  - Female
MH  - Humans
MH  - Male
MH  - Overweight/diagnosis/mortality
MH  - Proportional Hazards Models
MH  - Sex Factors
PMC - PMC3609520
EDAT- 2012/11/10 06:00
MHDA- 2013/09/21 06:00
PMCR- 2014/04/01
CRDT- 2012/11/10 06:00
PHST- 2012/11/10 06:00 [entrez]
PHST- 2012/11/10 06:00 [pubmed]
PHST- 2013/09/21 06:00 [medline]
PHST- 2014/04/01 00:00 [pmc-release]
AID - dc12-0944 [pii]
AID - 0944 [pii]
AID - 10.2337/dc12-0944 [doi]
PST - ppublish
SO  - Diabetes Care. 2013 Apr;36(4):887-93. doi: 10.2337/dc12-0944. Epub 2012 Nov 8.