PMID- 23140023
OWN - NLM
STAT- MEDLINE
DCOM- 20130107
LR  - 20121112
IS  - 0019-5189 (Print)
IS  - 0019-5189 (Linking)
VI  - 50
IP  - 9
DP  - 2012 Sep
TI  - Thirteen-week oral toxicity study of carotenoid pigment from Rhodotorula glutinis 
      DFR-PDY in rats.
PG  - 645-51
AB  - Carotenoids from some of the coloured yeasts like Rhodotorula, Phaffia rhodozyma 
      have attracted commercial interest as a natural pigment for foods. Red yeast 
      isolated from contaminated Potato dextrose agar plate (PDA), designated as 
      Rhodotorula glutinis DFR-PDY has been found to produce carotenoids. In the 
      present study toxicological evaluation of carotenoid pigment has been reported. 
      Experiment was conducted on 3 groups of albino rats. One group with vehicle 
      control (palm oil) and 2 groups with two different doses of red yeast pigment 
      (lower and higher dose) were fed to rats (both male and female) by gavages for 13 
      weeks. Gain in body weight of rats and food consumption were monitored at regular 
      intervals. Hematological studies revealed that there is no much difference in 
      erythrocytes, packed cell volume, Mean corpuscular volume (MCV), Mean corpuscular 
      haemoglobin concentration (MCHC), platelets and differential counts. Total 
      leucocyte count (TLC) is less in case of higher dose group than the lower and 
      control groups. Whereas, hemoglobin is more in case of higher dose than the lower 
      dose group and least in control group. Even clinico-chemical parameters and urine 
      analysis of vehicle control group and pigment fed rats revealed that there were 
      no major differences between them as well as between two different genders of 
      rats and also interaction between different doses and the genders. Histopathology 
      of these experimental animals revealed that there are no major histological 
      changes found between the groups. It may be concluded that the whole pigment 
      extract from R. glutinis DFR-PDY may be used safely in food preparations as food 
      colourant with an added benefit of antioxidant activity.
FAU - Latha, B V
AU  - Latha BV
AD  - Microbiology Discipline, Defence Food Research Laboratory, Siddarthanagar, Mysore 
      570 011, India.
FAU - Jeevaratanm, K
AU  - Jeevaratanm K
LA  - eng
PT  - Journal Article
PL  - India
TA  - Indian J Exp Biol
JT  - Indian journal of experimental biology
JID - 0233411
RN  - 0 (Antioxidants)
RN  - 0 (Pigments, Biological)
RN  - 36-88-4 (Carotenoids)
SB  - IM
MH  - Animals
MH  - Antioxidants/metabolism
MH  - Blood Cell Count
MH  - Body Weight/drug effects
MH  - Carotenoids/chemistry/*toxicity
MH  - Male
MH  - Organ Size/drug effects
MH  - Pigments, Biological/chemistry/*toxicity
MH  - Rats
MH  - Rats, Wistar
MH  - Rhodotorula/*chemistry
EDAT- 2012/11/13 06:00
MHDA- 2013/01/08 06:00
CRDT- 2012/11/13 06:00
PHST- 2012/11/13 06:00 [entrez]
PHST- 2012/11/13 06:00 [pubmed]
PHST- 2013/01/08 06:00 [medline]
PST - ppublish
SO  - Indian J Exp Biol. 2012 Sep;50(9):645-51.