PMID- 2314063 OWN - NLM STAT- MEDLINE DCOM- 19900425 LR - 20190510 IS - 0146-4760 (Print) IS - 0146-4760 (Linking) VI - 14 IP - 1 DP - 1990 Jan-Feb TI - Cross-reactivity of amphetamine analogues with Roche Abuscreen radioimmunoassay reagents. PG - 50-3 AB - Cross-reactivity of amphetamine analogues with the Abuscreen amphetamine radioimmunoassay reagents was determined for both the standard and high specificity antibody systems. Compounds tested included 2-methoxyamphetamine, 4-hydroxymethamphetamine, 2,5-dimethoxyamphetamine (DMA), 4-bromo-2,5-dimethoxyamphetamine (DOB), 4-bromo-2,5-dimethoxy-beta-phenethylamine (BDMPEA), 3,4,5-trimethoxyamphetamine (TMA), 3,4-methylenedioxyamphetamine (MDA), N,N-dimethyl-3,4-methylenedioxyamphetamine and N-hydroxy-3,4-methylenedioxyamphetamine (N-OH MDA), 3,4-methylenedioxymethamphetamine (MDMA), 3,4-methylenedioxyethylamphetamine (MDEA), 2,5-dimethoxy-4-ethylamphetamine, 2,5-dimethoxy-4-methylamphetamine (DOM), and 3,4,5-trimethoxyphenethylamine (mescaline). Blank negative reference material was spiked with 1,000 to 100,000 ng/mL of the amphetamine analogue and used as sample in the assays. MDA was the only analogue that showed cross reactivity equal to or greater than that of amphetamine. None of the other analogue compounds demonstrated a positive result at even the highest concentration; however several showed depressed counts at various concentration levels. FAU - Cody, J T AU - Cody JT AD - Air Force Drug Testing Laboratory, Brooks AFB, TX 78235-5000. LA - eng PT - Journal Article PL - England TA - J Anal Toxicol JT - Journal of analytical toxicology JID - 7705085 RN - 0 (Amphetamines) RN - 0 (Indicators and Reagents) RN - 0 (Iodine Radioisotopes) RN - 4764-17-4 (3,4-Methylenedioxyamphetamine) SB - IM MH - 3,4-Methylenedioxyamphetamine/analysis MH - Amphetamines/*analysis MH - Cross Reactions MH - Gas Chromatography-Mass Spectrometry MH - Humans MH - Indicators and Reagents MH - Iodine Radioisotopes MH - Radioimmunoassay MH - Substance Abuse Detection/*instrumentation MH - Substance-Related Disorders/*diagnosis/urine EDAT- 1990/01/01 00:00 MHDA- 1990/01/01 00:01 CRDT- 1990/01/01 00:00 PHST- 1990/01/01 00:00 [pubmed] PHST- 1990/01/01 00:01 [medline] PHST- 1990/01/01 00:00 [entrez] AID - 10.1093/jat/14.1.50 [doi] PST - ppublish SO - J Anal Toxicol. 1990 Jan-Feb;14(1):50-3. doi: 10.1093/jat/14.1.50.