PMID- 23140671
OWN - NLM
STAT- MEDLINE
DCOM- 20130607
LR  - 20211021
IS  - 1879-1379 (Electronic)
IS  - 0022-3956 (Print)
IS  - 0022-3956 (Linking)
VI  - 47
IP  - 2
DP  - 2013 Feb
TI  - Brain-derived neurotrophic factor (BDNF) Val66Met and adulthood chronic stress 
      interact to affect depressive symptoms.
PG  - 233-9
LID - S0022-3956(12)00322-6 [pii]
LID - 10.1016/j.jpsychires.2012.10.009 [doi]
AB  - BACKGROUND: BDNF Val66Met by chronic stress interaction has been studied using 
      childhood stress as a moderator, but has not been widely studied using chronic 
      stress in adulthood. METHODS: Two independent samples were used: Duke-CG (238 
      Caucasians) and MESA (5524 Caucasians, African Americans and Hispanics). Chronic 
      stress in Duke-CG was operationalized as having primary caregiving responsibility 
      for a spouse or relative with diagnosed Alzheimer's disease or other major 
      dementia; chronic stress in MESA was defined using chronic burden score 
      constructed from self-reported problems of health (self and someone close), job, 
      finance and relationships. CES-D scale was the measure of depression in both 
      samples. The BDNF Val66Met by adulthood chronic stress interaction predicting 
      CES-D was examined using linear regression, adjusted for covariates. RESULTS: The 
      main effect of BDNF Val66Met genotype on CES-D scores was non-significant (ps > 
      0.607) but the adulthood chronic stress indicator was significant (ps < 0.001) in 
      both samples. The BDNF Val66Met genotype by adulthood chronic stress interaction 
      was also significant (ps < 0.039) in both samples. The impact of chronic stress 
      in adulthood on CES-D scores was significantly larger in Val/Val genotype 
      individuals than Met carriers. CONCLUSION: We found in two independent samples 
      that depression levels increased significantly more as a function of adulthood 
      chronic stress Val/Val genotype carriers than Met carriers. Individuals with the 
      Val/Val genotype and chronic stress exposure could be targeted for interventions 
      designed to reduce risk of depression if this finding is confirmed in future 
      studies.
CI  - Copyright (c) 2012 Elsevier Ltd. All rights reserved.
FAU - Jiang, Rong
AU  - Jiang R
AD  - Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, 
      Durham, NC 27705, USA. rong.jiang@duke.edu
FAU - Brummett, Beverly H
AU  - Brummett BH
FAU - Babyak, Michael A
AU  - Babyak MA
FAU - Siegler, Ilene C
AU  - Siegler IC
FAU - Williams, Redford B
AU  - Williams RB
LA  - eng
GR  - N02-HL-6-4278/HL/NHLBI NIH HHS/United States
GR  - R01 AG019605/AG/NIA NIH HHS/United States
GR  - UL1 RR024156/RR/NCRR NIH HHS/United States
GR  - N01-HC-95159/HC/NHLBI NIH HHS/United States
GR  - N01-HC-95169/HC/NHLBI NIH HHS/United States
GR  - N01HC95159/HL/NHLBI NIH HHS/United States
GR  - N01HC65226/HL/NHLBI NIH HHS/United States
GR  - N01-HC-65226/HC/NHLBI NIH HHS/United States
GR  - N01HC95169/HL/NHLBI NIH HHS/United States
GR  - P01 HL036587/HL/NHLBI NIH HHS/United States
GR  - R01AG19605/AG/NIA NIH HHS/United States
GR  - M01 RR000030/RR/NCRR NIH HHS/United States
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, N.I.H., Extramural
DEP - 20121108
PL  - England
TA  - J Psychiatr Res
JT  - Journal of psychiatric research
JID - 0376331
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - AE28F7PNPL (Methionine)
RN  - HG18B9YRS7 (Valine)
SB  - IM
MH  - Adolescent
MH  - Aged
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Cohort Studies
MH  - Depression/complications/*genetics
MH  - Female
MH  - Genotype
MH  - Humans
MH  - Linear Models
MH  - Male
MH  - Methionine/*genetics
MH  - Middle Aged
MH  - Psychiatric Status Rating Scales
MH  - Stress, Psychological/complications/*genetics
MH  - Surveys and Questionnaires
MH  - Valine/*genetics
PMC - PMC3605893
MID - NIHMS417481
COIS- Conflict of interest: Redford B. Williams is a founder and major stockholder in 
      Williams LifeSkills, Inc.
EDAT- 2012/11/13 06:00
MHDA- 2013/06/08 06:00
PMCR- 2014/02/01
CRDT- 2012/11/13 06:00
PHST- 2012/06/18 00:00 [received]
PHST- 2012/09/27 00:00 [revised]
PHST- 2012/10/17 00:00 [accepted]
PHST- 2012/11/13 06:00 [entrez]
PHST- 2012/11/13 06:00 [pubmed]
PHST- 2013/06/08 06:00 [medline]
PHST- 2014/02/01 00:00 [pmc-release]
AID - S0022-3956(12)00322-6 [pii]
AID - 10.1016/j.jpsychires.2012.10.009 [doi]
PST - ppublish
SO  - J Psychiatr Res. 2013 Feb;47(2):233-9. doi: 10.1016/j.jpsychires.2012.10.009. 
      Epub 2012 Nov 8.