PMID- 23141153
OWN - NLM
STAT- MEDLINE
DCOM- 20130819
LR  - 20211021
IS  - 1873-7862 (Electronic)
IS  - 0924-977X (Print)
IS  - 0924-977X (Linking)
VI  - 23
IP  - 1
DP  - 2013 Jan
TI  - Decreased default network connectivity is associated with early life stress in 
      medication-free healthy adults.
PG  - 24-32
LID - S0924-977X(12)00287-8 [pii]
LID - 10.1016/j.euroneuro.2012.10.008 [doi]
AB  - Early life stress (ELS) is a significant risk factor for psychopathology, 
      although there are few functional imaging studies investigating its effects. 
      Previous literature suggests that ELS is associated with changes in structure and 
      function in the medial prefrontal cortex (MPFC), which forms the main anterior 
      node of the default network (DN). This study investigated the impact of ELS 
      history on resting state DN connectivity, using seed-based correlation analyses 
      (SCA) involving the posterior cingulate cortex (PCC). Data were analyzed from 22 
      adult subjects without psychiatric or medical illness (13 with and 9 without 
      ELS); none were taking psychotropic medication. Relative to controls, the ELS 
      group had significant decreases in DN connectivity, observed between the PCC seed 
      and the MPFC and inferior temporal cortex. Further analyses revealed a 
      trend-level increase in connectivity between the amygdala and MPFC associated 
      with ELS history. In conclusion, this study found that subjects with ELS, in the 
      absence of psychiatric illness and medication exposure, demonstrated decreased DN 
      connectivity, and trend-level increases in connectivity between the amygdala and 
      MPFC. These findings suggest that altered resting state connectivity is a 
      correlate of stress exposure, rather than a product of medication or psychiatric 
      morbidity.
CI  - Published by Elsevier B.V.
FAU - Philip, Noah S
AU  - Philip NS
AD  - Laboratory for Clinical and Translational Neuroscience, Butler Hospital, 
      Department of Psychiatry and Human Behavior, Alpert Medical School of Brown 
      University, Providence, RI 02906, USA. Noah_Philip@Brown.edu
FAU - Sweet, Lawrence H
AU  - Sweet LH
FAU - Tyrka, Audrey R
AU  - Tyrka AR
FAU - Price, Lawrence H
AU  - Price LH
FAU - Bloom, Rachel F
AU  - Bloom RF
FAU - Carpenter, Linda L
AU  - Carpenter LL
LA  - eng
GR  - R01 MH068767/MH/NIMH NIH HHS/United States
GR  - 5R01MH068767-08/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20121108
PL  - Netherlands
TA  - Eur Neuropsychopharmacol
JT  - European neuropsychopharmacology : the journal of the European College of 
      Neuropsychopharmacology
JID - 9111390
SB  - IM
MH  - Adolescent
MH  - *Adolescent Development
MH  - Adult
MH  - Amygdala/metabolism/pathology
MH  - Child
MH  - *Child Development
MH  - Diagnostic and Statistical Manual of Mental Disorders
MH  - Female
MH  - Gyrus Cinguli/*metabolism/pathology
MH  - Humans
MH  - Longitudinal Studies
MH  - Male
MH  - Middle Aged
MH  - Nerve Net/*metabolism/pathology
MH  - Neural Pathways
MH  - Pilot Projects
MH  - Prefrontal Cortex/*metabolism/pathology
MH  - Resilience, Psychological
MH  - Stress Disorders, Post-Traumatic/*metabolism/pathology/psychology
MH  - Stress, Psychological/metabolism/pathology/psychology
MH  - Temporal Lobe/*metabolism/pathology
PMC - PMC3581700
MID - NIHMS417692
COIS- Conflict of Interest Drs. Philip, Sweet, Tyrka, Price and Carpenter have received 
      research support from the National Institutes of Health. Dr. Philip has received 
      research support from Neuronetics and has served as a paid consultant to Gerson 
      Lehrman. Drs. Tyrka, Carpenter, and Price have received research support from 
      Cyberonics, the Department of Defense, Medtronic, and Neuronetics. Dr. Tyrka 
      received an honorarium for continuing medical education from Lundbeck. Dr. Price 
      has served as a paid consultant to Gerson Lehrman, and Dr. Price has served as a 
      paid consultant to Wiley, Springer, Qatar National Research Fund, Abbott, and 
      AstraZeneca. Dr. Carpenter has served as a paid consultant to Abbott, and also 
      acted in a consultant/speaker role without compensation for Neuronetics. Dr. 
      Sweet and Ms. Bloom report no biomedical financial interests or potential 
      conflicts of interest.
EDAT- 2012/11/13 06:00
MHDA- 2013/08/21 06:00
PMCR- 2014/01/01
CRDT- 2012/11/13 06:00
PHST- 2012/06/12 00:00 [received]
PHST- 2012/07/03 00:00 [revised]
PHST- 2012/10/18 00:00 [accepted]
PHST- 2012/11/13 06:00 [entrez]
PHST- 2012/11/13 06:00 [pubmed]
PHST- 2013/08/21 06:00 [medline]
PHST- 2014/01/01 00:00 [pmc-release]
AID - S0924-977X(12)00287-8 [pii]
AID - 10.1016/j.euroneuro.2012.10.008 [doi]
PST - ppublish
SO  - Eur Neuropsychopharmacol. 2013 Jan;23(1):24-32. doi: 
      10.1016/j.euroneuro.2012.10.008. Epub 2012 Nov 8.