PMID- 23141336
OWN - NLM
STAT- MEDLINE
DCOM- 20130423
LR  - 20131121
IS  - 1873-3573 (Electronic)
IS  - 0039-9140 (Linking)
VI  - 100
DP  - 2012 Oct 15
TI  - Synthesis and characterization of water-insoluble statistical copolymer and its 
      application in the development of electrochemical DNA sensor.
PG  - 270-5
LID - S0039-9140(12)00596-6 [pii]
LID - 10.1016/j.talanta.2012.07.020 [doi]
AB  - Water-insoluble statistical copolymer was synthesized by copolymerization of 
      methyl methacrylate (MMA) with 2-(dimethylamino)ethyl methacrylate (DMA) via 
      group transfer polymerization (GTP). The DMA residues of the precursor 
      P(MMA-co-DMA) statistical copolymer were then quaternized by reacting with methyl 
      iodide under mild conditions to get well-defined P(MMA-co-QDMA) cationic 
      copolymer. Then, P(MMA-co-QDMA) copolymer was successfully used for surface 
      modification of pencil graphite electrode (PGE) to develop a disposable DNA 
      sensor. This P(MMA-co-QDMA) copolymer modified electrode (q-PGE) was examined for 
      electrochemical monitoring of DNA by using differential pulse voltammetry (DPV) 
      in contrast to unmodified one. The effect of both DNA concentration and 
      sonication time was also examined based on the response of q-PGE. The detection 
      limit was calculated to be 8.06 mug/mL at q-PGE. Electrochemical impedance 
      spectroscopy (EIS) was used for the characterization of the surface modification 
      of q-PGE and consequently, the results were found to be in good agreement with 
      the voltammetric measurements.
CI  - Copyright (c) 2012 Elsevier B.V. All rights reserved.
FAU - Tuncer, Cansel
AU  - Tuncer C
AD  - Eskisehir Osmangazi University, Faculty of Arts and Science, Chemistry 
      Department, 26480 Eskisehir, Turkey.
FAU - Canavar, Ece
AU  - Canavar E
FAU - Congur, Gulsah
AU  - Congur G
FAU - Karadeniz, Hakan
AU  - Karadeniz H
FAU - Erdem, Arzum
AU  - Erdem A
FAU - Butun, Vural
AU  - Butun V
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120809
PL  - Netherlands
TA  - Talanta
JT  - Talanta
JID - 2984816R
RN  - 0 (Hydrocarbons, Iodinated)
RN  - 0 (PMAA-b-PDMAEMA)
RN  - 0 (Polymethacrylic Acids)
RN  - 059QF0KO0R (Water)
RN  - 9007-49-2 (DNA)
RN  - DAT010ZJSR (methyl iodide)
SB  - IM
MH  - Animals
MH  - Chemistry Techniques, Synthetic
MH  - DNA/*analysis/*chemistry
MH  - Electrochemistry/*methods
MH  - Hydrocarbons, Iodinated/chemistry
MH  - Polymerization
MH  - Polymethacrylic Acids/*chemical synthesis/*chemistry
MH  - Solubility
MH  - Water/*chemistry
EDAT- 2012/11/13 06:00
MHDA- 2013/04/24 06:00
CRDT- 2012/11/13 06:00
PHST- 2012/03/11 00:00 [received]
PHST- 2012/06/14 00:00 [revised]
PHST- 2012/07/08 00:00 [accepted]
PHST- 2012/11/13 06:00 [entrez]
PHST- 2012/11/13 06:00 [pubmed]
PHST- 2013/04/24 06:00 [medline]
AID - S0039-9140(12)00596-6 [pii]
AID - 10.1016/j.talanta.2012.07.020 [doi]
PST - ppublish
SO  - Talanta. 2012 Oct 15;100:270-5. doi: 10.1016/j.talanta.2012.07.020. Epub 2012 Aug 
      9.