PMID- 23141566
OWN - NLM
STAT- MEDLINE
DCOM- 20130815
LR  - 20131121
IS  - 1879-0372 (Electronic)
IS  - 0952-7915 (Linking)
VI  - 25
IP  - 1
DP  - 2013 Feb
TI  - Human leukocyte antigen-associated drug hypersensitivity.
PG  - 81-9
LID - S0952-7915(12)00157-4 [pii]
LID - 10.1016/j.coi.2012.10.002 [doi]
AB  - A growing number of associations between adverse drug reactions and alleles of 
      the human leukocyte antigen (HLA) genes are now known. Although several models 
      have been proposed to explain these associations, an underlying molecular basis 
      has only recently been described. The associations between HLA-B*57:01 and 
      abacavir hypersensitivity syndrome, and HLA-B*15:02 and carbamazepine-induced 
      bullous skin disease have provided new insights into the mechanism associated 
      with hypersensitivity reactions to these drugs. Here we discuss recent evidence 
      that small molecules can interact with specific HLA to distort self-peptide 
      presentation leading to autoimmune-like drug hypersensitivities that potentially 
      provide clues to the mechanisms underlying other immunopathologies.
CI  - Copyright (c) 2012 Elsevier Ltd. All rights reserved.
FAU - Illing, Patricia T
AU  - Illing PT
AD  - Department of Microbiology & Immunology, University of Melbourne, Parkville, 
      Victoria 3010, Australia.
FAU - Vivian, Julian P
AU  - Vivian JP
FAU - Purcell, Anthony W
AU  - Purcell AW
FAU - Rossjohn, Jamie
AU  - Rossjohn J
FAU - McCluskey, James
AU  - McCluskey J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20121108
PL  - England
TA  - Curr Opin Immunol
JT  - Current opinion in immunology
JID - 8900118
RN  - 0 (Anti-HIV Agents)
RN  - 0 (Anticonvulsants)
RN  - 0 (Autoantigens)
RN  - 0 (Dideoxynucleosides)
RN  - 0 (HLA Antigens)
RN  - 0 (Peptide Fragments)
RN  - 33CM23913M (Carbamazepine)
RN  - WR2TIP26VS (abacavir)
SB  - IM
MH  - Animals
MH  - Anti-HIV Agents/adverse effects/therapeutic use
MH  - Anticonvulsants/adverse effects/therapeutic use
MH  - Antigen Presentation/drug effects
MH  - Autoantigens/metabolism
MH  - Carbamazepine/adverse effects/therapeutic use
MH  - Dideoxynucleosides/adverse effects/therapeutic use
MH  - Drug Hypersensitivity/genetics/*immunology
MH  - HIV Infections/complications/*drug therapy
MH  - HLA Antigens/immunology/*metabolism
MH  - Humans
MH  - Peptide Fragments/metabolism
MH  - Protein Binding/drug effects
MH  - Seizures/*drug therapy
MH  - Skin/*drug effects/pathology
EDAT- 2012/11/13 06:00
MHDA- 2013/08/16 06:00
CRDT- 2012/11/13 06:00
PHST- 2012/10/01 00:00 [received]
PHST- 2012/10/03 00:00 [accepted]
PHST- 2012/11/13 06:00 [entrez]
PHST- 2012/11/13 06:00 [pubmed]
PHST- 2013/08/16 06:00 [medline]
AID - S0952-7915(12)00157-4 [pii]
AID - 10.1016/j.coi.2012.10.002 [doi]
PST - ppublish
SO  - Curr Opin Immunol. 2013 Feb;25(1):81-9. doi: 10.1016/j.coi.2012.10.002. Epub 2012 
      Nov 8.