PMID- 23141853
OWN - NLM
STAT- MEDLINE
DCOM- 20130823
LR  - 20211021
IS  - 1532-8414 (Electronic)
IS  - 1071-9164 (Print)
IS  - 1071-9164 (Linking)
VI  - 18
IP  - 11
DP  - 2012 Nov
TI  - Heart failure in post-MI patients with persistent IRA occlusion: prevalence, risk 
      factors, and the long-term effect of PCI in the Occluded Artery Trial (OAT).
PG  - 813-21
LID - S1071-9164(12)01289-4 [pii]
LID - 10.1016/j.cardfail.2012.10.012 [doi]
AB  - BACKGROUND: The incidence and predictors of heart failure (HF) after myocardial 
      infarction (MI) with modern post-MI treatment have not been well characterized. 
      METHODS AND RESULTS: A total of 2,201 stable patients with persistent 
      infarct-related artery occlusion >24 hours after MI with left ventricular 
      ejection fraction <50% and/or proximal coronary artery occlusion were randomized 
      to percutaneous intervention plus optimal medical therapy (PCI) or optimal 
      medical therapy (MED) alone. Centrally adjudicated HF hospitalizations for New 
      York Heart Association (NYHA) III/IV HF and mortality were determined in patients 
      with and without baseline HF, defined as a history of HF, Killip Class >I at 
      index MI, rales, S3 gallop, NYHA II at randomization, or NYHA >I before index MI. 
      Long-term follow-up data were used to determine 7-year life-table estimated event 
      rates and hazard ratios. There were 150 adjudicated HF hospitalizations during a 
      mean follow-up of 6 years with no difference between the randomized groups (7.4% 
      PCI vs. 7.5% MED, P = .97). Adjudicated HF hospitalization was associated with 
      subsequent death (44.0% vs. 13.1%, HR 3.31, 99% CI 2.21-4.92, P < .001). Baseline 
      HF (present in 32% of patients) increased the risk of adjudicated HF 
      hospitalization (13.6% vs. 4.7%, HR 3.43, 99% CI 2.23-5.26, P < .001) and death 
      (24.7% vs. 10.8%, HR 2.31, 99% CI 1.71-3.10, P < .001). CONCLUSIONS: In the 
      overall Occluded Artery Trial (OAT) population, adjudicated HF hospitalizations 
      occurred in 7.5% of subjects and were associated with increased risk of 
      subsequent death. Baseline or prior HF was common in the OAT population and was 
      associated with increased risk of hospitalization and death.
CI  - Copyright (c) 2012 Elsevier Inc. All rights reserved.
FAU - Jhaveri, Rahul R
AU  - Jhaveri RR
AD  - Cardiovascular Clinical Research Center, Leon Charney Division of Cardiology, New 
      York University School of Medicine, New York, NY 10016, USA.
FAU - Reynolds, Harmony R
AU  - Reynolds HR
FAU - Katz, Stuart D
AU  - Katz SD
FAU - Jeger, Raban
AU  - Jeger R
FAU - Zinka, Elzbieta
AU  - Zinka E
FAU - Forman, Sandra A
AU  - Forman SA
FAU - Lamas, Gervasio A
AU  - Lamas GA
FAU - Hochman, Judith S
AU  - Hochman JS
LA  - eng
SI  - ClinicalTrials.gov/NCT00004562
GR  - U01 HL062509/HL/NHLBI NIH HHS/United States
GR  - U01 HL062511/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Multicenter Study
PT  - Randomized Controlled Trial
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Card Fail
JT  - Journal of cardiac failure
JID - 9442138
SB  - IM
MH  - Aged
MH  - Coronary Occlusion/complications/*epidemiology/therapy
MH  - Female
MH  - Follow-Up Studies
MH  - Heart Failure/complications/*epidemiology/therapy
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Myocardial Infarction/complications/*epidemiology/therapy
MH  - *Percutaneous Coronary Intervention/trends
MH  - Prevalence
MH  - Risk Factors
MH  - Time Factors
MH  - Treatment Outcome
PMC - PMC3518044
MID - NIHMS417171
EDAT- 2012/11/13 06:00
MHDA- 2013/08/24 06:00
PMCR- 2013/11/01
CRDT- 2012/11/13 06:00
PHST- 2012/04/17 00:00 [received]
PHST- 2012/10/05 00:00 [revised]
PHST- 2012/10/05 00:00 [accepted]
PHST- 2012/11/13 06:00 [entrez]
PHST- 2012/11/13 06:00 [pubmed]
PHST- 2013/08/24 06:00 [medline]
PHST- 2013/11/01 00:00 [pmc-release]
AID - S1071-9164(12)01289-4 [pii]
AID - 10.1016/j.cardfail.2012.10.012 [doi]
PST - ppublish
SO  - J Card Fail. 2012 Nov;18(11):813-21. doi: 10.1016/j.cardfail.2012.10.012.