PMID- 23142609
OWN - NLM
STAT- MEDLINE
DCOM- 20130604
LR  - 20211021
IS  - 1872-7549 (Electronic)
IS  - 0166-4328 (Print)
IS  - 0166-4328 (Linking)
VI  - 239
DP  - 2013 Feb 15
TI  - Antidepressant-like effects of curcumin in WKY rat model of depression is 
      associated with an increase in hippocampal BDNF.
PG  - 27-30
LID - S0166-4328(12)00699-7 [pii]
LID - 10.1016/j.bbr.2012.10.049 [doi]
AB  - Curcumin is the principal active ingredient found in turmeric (Curcuma longa), a 
      plant used in traditional Asian diets and herbal medicines. It is known to have a 
      wide range of biological actions including antidepressant-like effects which have 
      been observed in stress-induced depression models. This study was designed to 
      investigate the antidepressant potential of curcumin in a non-induced model of 
      depression. Moreover, since brain derived neurotrophic factor (BDNF) has been 
      implicated in antidepressant effects of many drugs, we also evaluated the effects 
      of curcumin on BDNF in the hippocampus. Adult male Wistar Kyoto (WKY) rats, a 
      putative model of depression, were injected acutely or chronically (10d) with 50, 
      100, and 200mg/kg curcumin. Open field locomotor activity (OFLA) and forced swim 
      test (FST), a measure of helplessness, were measured 1h after acute and 18-20h 
      after last chronic injection. Results showed a dose-dependent reduction of 
      immobility in the FST by curcumin in both acute and chronic studies, without any 
      significant effect on OFLA. The effect of higher chronic curcumin dose in FST was 
      still evident a week later. Chronic curcumin also resulted in a dose-dependent 
      increase in hippocampal BDNF. This data provides evidence for an 
      antidepressant-like effect of curcumin, possibly through increased neurotrophic 
      activity, in the WKY model of depression, and support the notion that curcumin 
      may prove an effective and lasting natural antidepressant.
CI  - Copyright (c) 2012 Elsevier B.V. All rights reserved.
FAU - Hurley, Laura L
AU  - Hurley LL
AD  - Department of Pharmacology, Howard University College of Medicine, 520 W Street 
      NW, Washington, DC, United States.
FAU - Akinfiresoye, Luli
AU  - Akinfiresoye L
FAU - Nwulia, Evaristus
AU  - Nwulia E
FAU - Kamiya, Atsushi
AU  - Kamiya A
FAU - Kulkarni, Amol A
AU  - Kulkarni AA
FAU - Tizabi, Yousef
AU  - Tizabi Y
LA  - eng
GR  - S06 GM008016/GM/NIGMS NIH HHS/United States
GR  - 2 SO6 GM08016-39/GM/NIGMS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20121108
PL  - Netherlands
TA  - Behav Brain Res
JT  - Behavioural brain research
JID - 8004872
RN  - 0 (Antidepressive Agents)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - IT942ZTH98 (Curcumin)
SB  - IM
MH  - Animals
MH  - Antidepressive Agents/*pharmacology/therapeutic use
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Curcumin/*pharmacology/therapeutic use
MH  - Depression/*drug therapy/metabolism
MH  - *Disease Models, Animal
MH  - Dose-Response Relationship, Drug
MH  - Helplessness, Learned
MH  - Hippocampus/drug effects/*metabolism
MH  - Male
MH  - Motor Activity/drug effects
MH  - Rats
MH  - Rats, Inbred WKY
MH  - Rats, Wistar
PMC - PMC3525727
MID - NIHMS424424
EDAT- 2012/11/13 06:00
MHDA- 2013/06/05 06:00
PMCR- 2014/02/15
CRDT- 2012/11/13 06:00
PHST- 2012/09/05 00:00 [received]
PHST- 2012/10/25 00:00 [revised]
PHST- 2012/10/28 00:00 [accepted]
PHST- 2012/11/13 06:00 [entrez]
PHST- 2012/11/13 06:00 [pubmed]
PHST- 2013/06/05 06:00 [medline]
PHST- 2014/02/15 00:00 [pmc-release]
AID - S0166-4328(12)00699-7 [pii]
AID - 10.1016/j.bbr.2012.10.049 [doi]
PST - ppublish
SO  - Behav Brain Res. 2013 Feb 15;239:27-30. doi: 10.1016/j.bbr.2012.10.049. Epub 2012 
      Nov 8.