PMID- 23142685
OWN - NLM
STAT- MEDLINE
DCOM- 20130613
LR  - 20131123
IS  - 1095-8304 (Electronic)
IS  - 0195-6663 (Linking)
VI  - 61
IP  - 1
DP  - 2013 Feb
TI  - Rapid development of semistarvation-induced hyperactivity in Dark Agouti rats. 
      Excessive wheel running and effect of 3,4-methylenedioxymethamphetamine (MDMA).
PG  - 30-5
LID - S0195-6663(12)00442-4 [pii]
LID - 10.1016/j.appet.2012.10.026 [doi]
AB  - Clinical studies have found that patients with anorexia develop high activity 
      levels. These data suggest a possible implication of activity in the aetiology of 
      anorexia and are in line with findings obtained in animals during experimental 
      procedures to model interactions between activity and weight loss. Activity-based 
      anorexia (ABA) and semistarvation-induced hyperactivity (SIH) develop when 
      laboratory rats have food access restricted to a single period in the day and are 
      given free access to an activity wheel. This experiment sought to show the effect 
      on weight loss of the excessive activity normally seen in Dark Agouti rats and of 
      hyperactivity induced by 3,4-methylenedioxymethamphetamine (MDMA). To this end, 
      32 female rats of the Dark Agouti strain were selected and divided into four 
      groups in accordance with a 2 x 2 factorial design, in which one factor was 
      treatment (saline or MDMA) and the other was access or lack of access to an 
      activity wheel. Animals with wheel running access displayed a marked increase in 
      running combined with accelerated weight loss. Although pharmacological treatment 
      resulted in no observable effect on weight loss, rats treated with 12.5mg/kg MDMA 
      generally registered more wheel running than did those treated with saline. 
      Analysis of data on the temporal distribution of wheel running revealed an 
      alteration in circadian activity patterns as a consequence of MDMA. These 
      results, by showing a general high level of wheel running in Dark Agouti rats, 
      once again emphasise the close relationship between activity and weight loss in 
      the development of SIH and related phenomena such as ABA.
CI  - Copyright (c) 2012 Elsevier Ltd. All rights reserved.
FAU - Vidal, Pedro
AU  - Vidal P
AD  - Laboratorios de Conducta Animal, Departamento de Psicologia Basica I, Facultad de 
      Psicologia, Universidad Nacional de Educacion a Distancia, 28040 Spain.
FAU - Perez-Padilla, Angeles
AU  - Perez-Padilla A
FAU - Pellon, Ricardo
AU  - Pellon R
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121108
PL  - England
TA  - Appetite
JT  - Appetite
JID - 8006808
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - Animals
MH  - Anorexia/complications/drug therapy/pathology
MH  - Circadian Rhythm/drug effects
MH  - Female
MH  - Hyperkinesis/drug therapy/etiology/*pathology
MH  - Motor Activity/*drug effects
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*administration & dosage/*adverse effects
MH  - Rats
MH  - Starvation/*metabolism
MH  - Weight Loss
EDAT- 2012/11/13 06:00
MHDA- 2013/06/14 06:00
CRDT- 2012/11/13 06:00
PHST- 2012/04/23 00:00 [received]
PHST- 2012/10/26 00:00 [revised]
PHST- 2012/10/30 00:00 [accepted]
PHST- 2012/11/13 06:00 [entrez]
PHST- 2012/11/13 06:00 [pubmed]
PHST- 2013/06/14 06:00 [medline]
AID - S0195-6663(12)00442-4 [pii]
AID - 10.1016/j.appet.2012.10.026 [doi]
PST - ppublish
SO  - Appetite. 2013 Feb;61(1):30-5. doi: 10.1016/j.appet.2012.10.026. Epub 2012 Nov 8.