PMID- 23143881
OWN - NLM
STAT- MEDLINE
DCOM- 20130627
LR  - 20211021
IS  - 1559-1166 (Electronic)
IS  - 0895-8696 (Linking)
VI  - 49
IP  - 2
DP  - 2013 Feb
TI  - Protective effects of BDNF overexpression bone marrow stromal cell 
      transplantation in rat models of traumatic brain injury.
PG  - 409-16
LID - 10.1007/s12031-012-9908-0 [doi]
AB  - Bone marrow stromal cells (MSCs) were used as cell therapy for various diseases 
      in recent years. Some reports showed that transplanted MSCs promote functional 
      recovery in animal models of brain trauma. But other studies indicate that tissue 
      replacement by this method may not be the main source of therapeutic benefit. 
      Neurotrophic factors such as brain-derived neurotrophic factor (BDNF) therapeutic 
      potential may contribute to the recovery of function after trauma. Our previous 
      study showed that BDNF-MSCs could promote the survival of neurons in neuronal 
      injured models in vitro. The present study was undertaken to explore the 
      therapeutic effects of MSCs transfected with BDNF in vivo. After intraventricular 
      injection of MSCs-BDNF, BDNF levels were increased significantly in cerebrospinal 
      fluid by ELISA. Further studies showed that treatment of traumatic brain injury 
      with MSCs-BDNF could attenuate neuronal injury as measurement of biological 
      behavior assessment. These studies demonstrate that by increasing the brain 
      concentration of BDNF, intraventricularly transplanted MSCs-BDNF might play an 
      important role in the treatment of traumatic brain injury and might be an 
      optional therapeutic strategy.
FAU - Wang, Zhitao
AU  - Wang Z
AD  - Department of Neurosurgery, Tianjin Medical University General Hospital, Tianjin, 
      300052, People's Republic of China.
FAU - Yao, Weifeng
AU  - Yao W
FAU - Deng, Quanjun
AU  - Deng Q
FAU - Zhang, Xiaohui
AU  - Zhang X
FAU - Zhang, Jianning
AU  - Zhang J
LA  - eng
PT  - Journal Article
DEP - 20121111
PL  - United States
TA  - J Mol Neurosci
JT  - Journal of molecular neuroscience : MN
JID - 9002991
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Animals
MH  - Brain Injuries/pathology/physiopathology/*therapy
MH  - Brain-Derived Neurotrophic Factor/cerebrospinal 
      fluid/genetics/*metabolism/therapeutic use
MH  - Female
MH  - Gene Expression
MH  - Injury Severity Score
MH  - *Mesenchymal Stem Cell Transplantation
MH  - Mesenchymal Stem Cells/metabolism
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Transfection
EDAT- 2012/11/13 06:00
MHDA- 2013/06/29 06:00
CRDT- 2012/11/13 06:00
PHST- 2012/07/24 00:00 [received]
PHST- 2012/10/16 00:00 [accepted]
PHST- 2012/11/13 06:00 [entrez]
PHST- 2012/11/13 06:00 [pubmed]
PHST- 2013/06/29 06:00 [medline]
AID - 10.1007/s12031-012-9908-0 [doi]
PST - ppublish
SO  - J Mol Neurosci. 2013 Feb;49(2):409-16. doi: 10.1007/s12031-012-9908-0. Epub 2012 
      Nov 11.