PMID- 23144589
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211021
IS  - 1479-6708 (Print)
IS  - 1748-6971 (Electronic)
IS  - 1479-6708 (Linking)
VI  - 7
IP  - 6
DP  - 2012 Nov
TI  - A Critical Kinase Cascade in Neurological Disorders: PI 3-K, Akt, and mTOR.
PG  - 733-748
AB  - Neurodegenerative disorders lead to disability and death in a significant 
      proportion of the world's population. However, many disorders of the nervous 
      system remain with limited effective treatments. Kinase pathways in the nervous 
      system that involve phosphoinositide 3-kinase (PI 3-K), protein kinase B (Akt), 
      and the mammalian target of rapamycin (mTOR) offer exciting prospects for the 
      understanding of neurodegenerative pathways and the development of new avenues of 
      treatment. PI 3-K, Akt, and mTOR pathways are vital cellular components that 
      determine cell fate during acute and chronic disorders, such as Huntington's 
      disease, Alzheimer's disease, Parkinson's disease, epilepsy, stroke, and trauma. 
      Yet, the elaborate relationship among these kinases and the variable control of 
      apoptosis and autophagy can lead to unanticipated biological and clinical 
      outcomes. Crucial for the successful translation of PI 3-K, Akt, and mTOR into 
      robust and safe clinical strategies will be the further elucidation of the 
      complex roles that these kinase pathways hold in the nervous system.
FAU - Chong, Zhao Zhong
AU  - Chong ZZ
AD  - Laboratory of Cellular and Molecular Signaling, Newark, New Jersey 07101 ; New 
      Jersey Health Sciences University, Newark, New Jersey 07101.
FAU - Shang, Yan Chen
AU  - Shang YC
FAU - Wang, Shaohui
AU  - Wang S
FAU - Maiese, Kenneth
AU  - Maiese K
LA  - eng
GR  - R01 NS053946/NS/NINDS NIH HHS/United States
PT  - Journal Article
PL  - England
TA  - Future Neurol
JT  - Future neurology
JID - 101278119
PMC - PMC3491909
MID - NIHMS413969
EDAT- 2012/11/13 06:00
MHDA- 2012/11/13 06:01
PMCR- 2012/11/07
CRDT- 2012/11/13 06:00
PHST- 2012/11/13 06:00 [entrez]
PHST- 2012/11/13 06:00 [pubmed]
PHST- 2012/11/13 06:01 [medline]
PHST- 2012/11/07 00:00 [pmc-release]
AID - 10.2217/fnl.12.72 [doi]
PST - ppublish
SO  - Future Neurol. 2012 Nov;7(6):733-748. doi: 10.2217/fnl.12.72.