PMID- 2314473
OWN - NLM
STAT- MEDLINE
DCOM- 19900426
LR  - 20220310
IS  - 0028-0836 (Print)
IS  - 0028-0836 (Linking)
VI  - 344
IP  - 6264
DP  - 1990 Mar 22
TI  - Identification and characterization of a novel member of the nerve growth 
      factor/brain-derived neurotrophic factor family.
PG  - 339-41
AB  - The survival and functional maintenance of vertebrate neurons critically depends 
      on the availability of specific neurotrophic factors. So far, only two such 
      factors, nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) 
      have been characterized and shown to have the typical features of secretory 
      proteins. This characterization has been possible because of the extraordinarily 
      large quantities of NGF in some adult tissues, and the virtually unlimited 
      availability of brain tissue from which BDNF was isolated. Both NGF and BDNF 
      promote the survival of distinct neuronal populations in vivo and are related in 
      their primary structure, suggesting that they are members of a gene family. 
      Although there is little doubt about the existence of other such proteins, their 
      low abundance has rendered their identification and characterization difficult. 
      Taking advantage of sequence identities between NGF and BDNF, we have now 
      identified a third member of this family, which we name neurotrophin-3. Both the 
      tissue distribution of the messenger RNA and the neuronal specificity of this 
      secretory protein differ from those of NGF and BDNF. Alignment of the sequences 
      of the three proteins reveals a remarkable number of amino acid identities, 
      including all cysteine residues. This alignment also delineates four variable 
      domains, each of 7-11 amino acids, indicating structural elements presumably 
      involved in the neuronal specificity of these proteins.
FAU - Hohn, A
AU  - Hohn A
AD  - Max-Planck-Institut for Psychiatry, Department of Neurochemistry, 
      Planegg-Martinsried, FRG.
FAU - Leibrock, J
AU  - Leibrock J
FAU - Bailey, K
AU  - Bailey K
FAU - Barde, Y A
AU  - Barde YA
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Nature
JT  - Nature
JID - 0410462
RN  - 0 (Nerve Growth Factors)
RN  - 0 (Neurotrophin 3)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Base Sequence
MH  - Cloning, Molecular
MH  - Mice
MH  - Molecular Sequence Data
MH  - Nerve Growth Factors/*genetics
MH  - Neurons/*physiology
MH  - Neurotrophin 3
MH  - Polymerase Chain Reaction
MH  - Tissue Distribution
EDAT- 1990/03/22 00:00
MHDA- 1990/03/22 00:01
CRDT- 1990/03/22 00:00
PHST- 1990/03/22 00:00 [pubmed]
PHST- 1990/03/22 00:01 [medline]
PHST- 1990/03/22 00:00 [entrez]
AID - 10.1038/344339a0 [doi]
PST - ppublish
SO  - Nature. 1990 Mar 22;344(6264):339-41. doi: 10.1038/344339a0.