PMID- 23146833
OWN - NLM
STAT- MEDLINE
DCOM- 20130610
LR  - 20121231
IS  - 1873-2941 (Electronic)
IS  - 0009-3084 (Linking)
VI  - 165
IP  - 8
DP  - 2012 Dec
TI  - Enhanced lysophosphatidylcholine and sphingomyelin contents are characteristic of 
      spermatozoa from obese men-A MALDI mass spectrometric study.
PG  - 861-5
LID - S0009-3084(12)00117-X [pii]
LID - 10.1016/j.chemphyslip.2012.11.001 [doi]
AB  - The lipids of human spermatozoa are characterized by unique fatty acyl 
      compositions, i.e. considerable amounts of highly unsaturated, in particular 
      docosahexaenoyl (22:6) fatty acyl residues. This makes spermatozoa very sensitive 
      to oxidation. It has already been shown that the most abundant lipid of sperm, 
      phosphatidylcholine (PC), is converted into lysophosphatidylcholine (LPC) under 
      conditions of oxidative stress, and, thus, the PC/LPC ratio may be used as a 
      measure of sperm quality. However, direct correlations between the PC/LPC ratios 
      and certain pathologies are so far missing. We will show here for the first time 
      (by using matrix-assisted laser desorption and ionization time-of-flight 
      (MALDI-TOF) mass spectrometry (MS)) that sperm from obese donors (BMI>35kg/m(2)) 
      are characterized by (a) a significantly increased LPC as well as (b) an 
      increased sphingomyelin content. This does exclusively hold true for the lipid 
      extracts of the spermatozoa but is not valid for the related seminal fluids.
CI  - Copyright (c) 2012 Elsevier Ireland Ltd. All rights reserved.
FAU - Pyttel, Susanne
AU  - Pyttel S
AD  - Department of Dermatology, Training Center of the European Academy of Andrology, 
      University of Leipzig, Philipp-Rosenthal-Strasse 23, D-04103 Leipzig, Germany.
FAU - Zschornig, Kristin
AU  - Zschornig K
FAU - Nimptsch, Ariane
AU  - Nimptsch A
FAU - Paasch, Uwe
AU  - Paasch U
FAU - Schiller, Jurgen
AU  - Schiller J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121110
PL  - Ireland
TA  - Chem Phys Lipids
JT  - Chemistry and physics of lipids
JID - 0067206
RN  - 0 (Lysophosphatidylcholines)
RN  - 0 (Sphingomyelins)
SB  - IM
MH  - Adult
MH  - Body Mass Index
MH  - Humans
MH  - Lysophosphatidylcholines/*analysis
MH  - Male
MH  - Middle Aged
MH  - Obesity/*metabolism/pathology
MH  - *Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
MH  - Sperm Motility
MH  - Spermatozoa/*chemistry/physiology
MH  - Sphingomyelins/*analysis
EDAT- 2012/11/14 06:00
MHDA- 2013/06/12 06:00
CRDT- 2012/11/14 06:00
PHST- 2012/06/20 00:00 [received]
PHST- 2012/10/25 00:00 [revised]
PHST- 2012/11/02 00:00 [accepted]
PHST- 2012/11/14 06:00 [entrez]
PHST- 2012/11/14 06:00 [pubmed]
PHST- 2013/06/12 06:00 [medline]
AID - S0009-3084(12)00117-X [pii]
AID - 10.1016/j.chemphyslip.2012.11.001 [doi]
PST - ppublish
SO  - Chem Phys Lipids. 2012 Dec;165(8):861-5. doi: 10.1016/j.chemphyslip.2012.11.001. 
      Epub 2012 Nov 10.