PMID- 23147524
OWN - NLM
STAT- MEDLINE
DCOM- 20130227
LR  - 20211021
IS  - 1572-0241 (Electronic)
IS  - 0002-9270 (Print)
IS  - 0002-9270 (Linking)
VI  - 108
IP  - 1
DP  - 2013 Jan
TI  - Helicobacter pylori-negative gastritis: prevalence and risk factors.
PG  - 65-71
LID - 10.1038/ajg.2012.372 [doi]
AB  - OBJECTIVES: Recent studies using histology alone in select patients have 
      suggested that Helicobacter pylori-negative gastritis may be common. The 
      objective of this study was to investigate the prevalence of H. pylori among 
      individuals with histologic gastritis. METHODS: Subjects between 40 and 80 years 
      underwent elective esophagogastroduodenoscopy at a VA Medical Center. Gastric 
      biopsies were mapped from seven prespecified sites (two antrum, four corpus, and 
      one cardia) and graded by two gastrointestinal pathologists, using the Updated 
      Sydney System. H. pylori-negative required four criteria: negative triple 
      staining at all seven gastric sites, negative H. pylori culture, negative IgG H. 
      pylori serology, and no previous treatment for H. pylori. Data regarding tobacco 
      smoking, alcohol drinking, nonsteroidal anti-inflammatory drug, and proton pump 
      inhibitor (PPI) use were obtained by questionnaire. RESULTS: Of the 491 
      individuals enrolled, 40.7% (200) had gastritis of at least grade 2 in at least 
      one biopsy site or grade 1 in at least two sites. Forty-one (20.5%) had H. 
      pylori-negative gastritis; most (30 or 73.2%) had chronic gastritis, five (12.2%) 
      had active gastritis, and six (14.6%) had both. H. pylori-negative gastritis was 
      approximately equally distributed in the antrum, corpus, and both antrum and 
      corpus. Past and current PPI use was more frequent in H. pylori-negative vs. H. 
      pylori-positive gastritis (68.2% and 53.8%; P=0.06). CONCLUSIONS: We used 
      multiple methods to define non-H. pylori gastritis and found it in 21% of 
      patients with histologic gastritis. While PPI use is a potential risk factor, the 
      cause or implications of this entity are not known.
FAU - Nordenstedt, Helena
AU  - Nordenstedt H
AD  - Houston VA HSR&D Center of Excellence, Houston, TX, USA.
FAU - Graham, David Y
AU  - Graham DY
FAU - Kramer, Jennifer R
AU  - Kramer JR
FAU - Rugge, Massimo
AU  - Rugge M
FAU - Verstovsek, Gordana
AU  - Verstovsek G
FAU - Fitzgerald, Stephanie
AU  - Fitzgerald S
FAU - Alsarraj, Abeer
AU  - Alsarraj A
FAU - Shaib, Yasser
AU  - Shaib Y
FAU - Velez, Maria E
AU  - Velez ME
FAU - Abraham, Neena
AU  - Abraham N
FAU - Anand, Bhupinderjit
AU  - Anand B
FAU - Cole, Rhonda
AU  - Cole R
FAU - El-Serag, Hashem B
AU  - El-Serag HB
LA  - eng
GR  - P30 DK056338/DK/NIDDK NIH HHS/United States
GR  - R01 116845/PHS HHS/United States
GR  - DK K24-04-107/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20121113
PL  - United States
TA  - Am J Gastroenterol
JT  - The American journal of gastroenterology
JID - 0421030
SB  - IM
CIN - Am J Gastroenterol. 2013 Jan;108(1):72-4. PMID: 23287944
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Biopsy
MH  - Cross-Sectional Studies
MH  - Endoscopy, Digestive System
MH  - Female
MH  - Gastric Mucosa/microbiology/pathology
MH  - Gastritis/epidemiology/*etiology/microbiology/pathology
MH  - Health Surveys
MH  - Helicobacter Infections/*complications/epidemiology/pathology
MH  - Helicobacter pylori/*isolation & purification
MH  - Humans
MH  - Logistic Models
MH  - Male
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Prevalence
MH  - Risk Factors
MH  - Surveys and Questionnaires
MH  - Texas/epidemiology
PMC - PMC3984401
MID - NIHMS564483
COIS- Potential competing interests: None.
EDAT- 2012/11/14 06:00
MHDA- 2013/02/28 06:00
PMCR- 2014/04/12
CRDT- 2012/11/14 06:00
PHST- 2012/11/14 06:00 [entrez]
PHST- 2012/11/14 06:00 [pubmed]
PHST- 2013/02/28 06:00 [medline]
PHST- 2014/04/12 00:00 [pmc-release]
AID - ajg2012372 [pii]
AID - 10.1038/ajg.2012.372 [doi]
PST - ppublish
SO  - Am J Gastroenterol. 2013 Jan;108(1):65-71. doi: 10.1038/ajg.2012.372. Epub 2012 
      Nov 13.